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Evidence-based Complementary and Alternative Medic... 760건

  1. [해외논문]   KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells  

    Lee, Dong-Sung (Inha Research Institute for Medical Sciences, Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Republic of Korea ) , Ko, Wonmin (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea ) , Yoon, Chi-Su (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea ) , Kim, Dong-Cheol (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea ) , Yun, Jinju (Hanpoong Pharm & Foods Co., Ltd., Jeonju, 561-841, Republic of Korea ) , Lee, Jun-Kyung (Hanpoong Pharm & Foods Co., Ltd., Jeonju, 561-841, Republic of Korea ) , Jun, Ki-Young (Hanpoong Pharm & Foods Co., Ltd., Jeonju, 561-841, Republic of Korea ) , Son, Ilhong (Department of Neurology, Inam Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Iksan 570-749, Republic of Korea ) , Kim, Dong-Woung (Department of Internal Medicine, Wonkwang University College of Korean Medicine, Iksan) , Song, Bong-Keun , Choi, Seulah , Jang, Jun-Hyeog , Oh, Hyuncheol , Kim, Sungchul , Kim, Youn-Chul
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 357154 , 2014 , 1741-427x ,

    초록

    The brain is vulnerable to oxidative stress and inflammation that can occur as a result of aging or neurodegenerative diseases. Our work has sought to identify natural products that regulate heme oxygenase (HO)-1 and to determine their mechanism of action in neurodegenerative diseases. KCHO-1 is a novel herbal therapeutic containing 30% ethanol (EtOH) extracts from nine plants. In this study, we investigated the antineuroinflammatory effects of KCHO-1 in lipopolysaccharide- (LPS-) treated mouse BV2 microglia. KCHO-1 inhibited the protein expression of inducible nitric oxide synthase (iNOS), iNOS-derived nitric oxide (NO), cyclooxygenase- (COX-) 2, and COX-2-derived prostaglandin E2 (PGE 2 ) in LPS-stimulated BV2 microglia. It also reduced tumor necrosis factor- α (TNF- α ), interleukin-1 β (IL-1 β ), and IL-6 production. This effect was correlated with the suppression of inhibitor of nuclear factor kappa B- α (I κ B- α ) phosphorylation and degradation and nuclear factor kappa B (NF- κ B) translocation and DNA binding. Additionally, KCHO-1 upregulated HO-1 expression by promoting nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in mouse BV2 microglia. Tin protoporphyrin (SnPP), an HO activity inhibitor, was used to verify the inhibitory effects of KCHO-1 on proinflammatory mediators and proteins associated with HO-1 expression. Our data suggest that KCHO-1 has therapeutic potential in neurodegenerative diseases caused by neuroinflammation.

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  2. [해외논문]   Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity  

    Jeong, Soo-Jin (Herbal Medicine Formulation Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea ) , Seo, Chang-Seob (Herbal Medicine Formulation Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea ) , Huh, Jung-Im (Division of Non-Clinical Studies, Korea Institute of Toxicology, Daejeon 305-343, Republic of Korea ) , Shin, Hyeun-Kyoo (Herbal Medicine Formulation Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 362573 , 2014 , 1741-427x ,

    초록

    Background . The traditional herbal formula Yukmijiwhang-tang (YMJ) consists of six medicinal herbs and has been used to treat dysuria, diabetic mellitus, and neurosis in Korea, China, and Japan. Here we report safety information on its subacute toxicity and the cytotoxicity. Methods . YMJ extract was administered to SD rats at various dosages for 4 weeks. We monitored clinical signs, mortality, body and organ weights, food intake, and hematological and serum biochemistry factors. For cytotoxicity testing, each cell line was treated with various concentrations of YMJ for 24 h. Results . YMJ treatment had no significant effects on changes in clinical signs, body weight, or food intake in male or female rats. In male rats, YMJ treatment decreased the absolute weights of the epididymides and serum Na levels. In female rats, YMJ significantly reduced the prothrombin time (PT) and serum creatine level. However, the changes were not severe and were considered to be in the normal physiological range for rats. The no-observed-adverse-effect-level (NOAEL) was estimated to be 2000 mg/kg/day. YMJ extract did not exert any cytotoxicity against 23 tested cell lines. Conclusions . Our data provide scientific evidence on the safety of YMJ for potential development as a prescription drug.

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  3. [해외논문]   Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis  

    Xing, Shu-huai (Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, Liaoning 110001, China ) , Zhu, Chun-xiao (Shunyi District Centers for Diseases Control and Prevention, Beijing 101300, China ) , Zhang, Rui (Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, Liaoning 110001, China ) , An, Li (Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, Liaoning 110001, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 363985 , 2014 , 1741-427x ,

    초록

    The objective of our study was to perform an updated meta-analysis of placebo-controlled RCTs of Huperzine A (Hup A) on patients with Alzheimer's disease (AD) and vascular dementia (VD), in order to provide the basis and reference for clinical rational drug use. The primary outcome measures assessed were minimental state examination (MMSE) and activities of daily living scale (ADL). Eight AD trials with 733 participants and two VD trials with 92 participants that met our inclusion criteria were identified. The results showed that Hup A could significantly improve the MMSE and ADL score of AD and VD patients, and longer durations would result in better efficacy for the patients with AD. It seemed that there was significant improvement of cognitive function measured by memory quotient (MQ) in patients with AD. Most adverse effects in AD were generally of mild to moderate severity and transient. Compared to the patients with AD, Hup A may offer fewer side effects for participants with VD in this study. Therefore, Hup A is a well-tolerated drug that could significantly improve cognitive performance in patients with AD or VD, but we need to use it with caution in the clinical treatment.

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  4. [해외논문]   Ligand-Based and Structure-Based Investigation for Alzheimer's Disease from Traditional Chinese Medicine  

    Liao, Kai Hsin (School of Pharmacy, China Medical University, Taichung 40402, Taiwan ) , Chen, Kuen-Bao (School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan ) , Lee, Wen-Yuan (School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan ) , Sun, Mao-Feng (School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan ) , Lee, Cheng-Chun (School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan ) , Chen, Calvin Yu-Chian (School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 364819 , 2014 , 1741-427x ,

    초록

    Alzheimer's disease is a neurodegenerative disease that was conventionally thought to be related to the sedimentation of beta-amyloids, but drugs designed according to this hypothesis have generally failed. That FKBP52 can reduce the accumulation of tau proteins, and that Tacrolimus can reduce the pathological changes of tau proteins are new directions away from the long held amyloid-beta-centric concept. Therefore, the screening of traditional Chinese medicine compounds for those with higher affinity towards FKBP52 than Tacrolimus may be a new direction for treating Alzheimer's disease. This study utilizes ligand-based and structure-based methods as the foundation. By utilizing dock scores and the predicted pIC50 from SVM, MLR, and Bayesian Network, several TCM compounds were selected for further analysis of their protein-ligand interactions. Daphnetoxin has higher affinity and complex structure stability than Tacrolimus; Lythrancine II exhibits the most identical trends in FKBP52 interactions as Tacrolimus, and 20-O-(2′ E ,4′ E -decadienoyl)ingenol may be further modified at its hydrocarbon chain to promote interaction with FKBP52. In addition, we observed the residue Tyr113 of FKBP52 may play a key role in protein-ligand interaction. Our results indicate that Daphnetoxin, 20-O-(2′ E ,4′ E -decadienoyl)ingenol, and Lythrancine II may be starting points for further modification as a new type of non-amyloid-beta-centric drug for Alzheimer's disease.

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  5. [해외논문]   Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala  

    Chen, Liang (School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China ) , Yang, Yang (School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China ) , Yuan, Pulong (School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China ) , Yang, Yifu (School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China ) , Chen, Kaixian (School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China ) , Jia, Qi (School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China ) , Li, Yiming (School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 365258 , 2014 , 1741-427x ,

    초록

    Cinnamon barks extracts have been reported to regulate immune function; however, the component(s) in cinnamon barks responsible for this effect is/are not yet clear. The aim of this study is to find out the possible component(s) that can be used as therapeutic agents for immune-related diseases from cinnamon bark. In this study, the immunosuppressive effects of fraction (named CT-F) and five procyanidin oligomers compounds, cinnamtannin B1, cinnamtannin D1 (CTD-1), parameritannin A1, procyanidin B2, and procyanidin C1, from Cinnamomum tamala or Cinnamomum cassia bark were examined on splenocytes proliferation model induced by ConA or LPS. Then, the effects of activated compound CTD-1 on cytokine production and 2,4-dinitrofluorobenzene (DNFB) induced delayed-type hypersensitivity (DTH) response were detected to evaluate the immunosuppressive activity of CTD-1. It was found that CT-F and CTD-1 significantly inhibited the splenocyte proliferation induced by ConA or LPS. CTD-1 dose-dependently reduced the level of IFN- γ and IL-2 and intensively suppressed DNFB-induced DTH responses. These findings suggest that the immunosuppressive activities of cinnamon bark are in part due to procyanidin oligomers. CTD-1 may be a potential therapeutic agent for immune-related diseases.

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  6. [해외논문]   Evaluation of a Crataegus -Based Multiherb Formula for Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial  

    Hu, Miao (Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong ) , Zeng, Weiwei (Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong ) , Tomlinson, Brian (Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 365742 , 2014 , 1741-427x ,

    초록

    Background. We for the first time examined the effects of a multiherb formula containing Crataegus pinnatifida (1 g daily), Alisma orientalis , Stigma maydis , Ganoderma lucidum , Polygonum multiflorum , and Morus alba on plasma lipid and glucose levels in Chinese patients with dyslipidemia. Methods. In this randomized, double-blind, placebo-controlled study, 42 patients were randomized at a ratio of 1 : 1 to receive the herbal formula or placebo for 12 weeks and 40 patients completed the study. Lipid profiles, glucose, glycated haemoglobin (HbA1c), and laboratory safety parameters were performed before and after treatment. Results. The difference in the changes in low-density lipoprotein cholesterol (LDL-C) levels between placebo and active treatment (−9%) was significantly ( P P = 0.098). There were no apparent adverse effects or changes in laboratory safety parameters with either treatment. Conclusions. The multiherb formula had mild beneficial effects on plasma LDL-C after 12-weeks treatment in subjects with dyslipidemia without any noticeable adverse effects.

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  7. [해외논문]   Inhibitory Effect of a Hot-Water Extract of Leaves of Japanese Big-Leaf Magnolia ( Magnolia obovata ) on Rotavirus-Induced Diarrhea in Mouse Pups  

    Kawahara, Takeshi (Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan ) , Tomono, Takuma (Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan ) , Hamauzu, Yasunori (Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan ) , Tanaka, Katsumi (Kiso Town Resources Institute, 2326-6 Fukushima Kisomachi, Kiso-gun, Nagano 397-8588, Japan ) , Yasui, Hisako (Kiso Town Resources Institute, 2326-6 Fukushima Kisomachi, Kiso-gun, Nagano 397-8588, Japan)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 365831 , 2014 , 1741-427x ,

    초록

    The leaf of Japanese big-leaf magnolia ( Magnolia obovata Thunb.) has long been used as a natural packaging material for traditional foods in Japan. However, many of the physiological functions of the leaves against oral infection and resultant illness remain unclear. The aim of the present study was to investigate the effects of a hot-water extract of the leaves of Magnolia obovata on diarrhea induced by rotavirus (RV), a major cause of acute diarrhea. RV strain SA11 was mixed with the M. obovata leaf extract and inoculated orally to neonatal BALB/c mouse pups. Simultaneous inoculation of SA11 with the extract significantly decreased the incidence of diarrhea. In addition, the extract significantly inhibited cytopathic effects and mRNA expression of viral proteins in SA11-infected MA104 cells. Two flavonoid glycosides, quercitrin and rutin, were strongly suggested to be major anti-RV agents in the extract by serial solvent extraction and reversed-phase HPLC-ESI-MS analysis. Our results suggest that the hot-water extract of M. obovata leaves can be used as a medicine or food additive to prevent and ameliorate RV-induced diarrhea in individuals that may have difficulty in benefitting from the RV vaccines.

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  8. [해외논문]   GBE50 Attenuates Inflammatory Response by Inhibiting the p38 MAPK and NF- κ B Pathways in LPS-Stimulated Microglial Cells  

    He, Gai-ying (Department of Physiology, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China ) , Yuan, Chong-gang (Department of Physiology, College of Life Science, East China Normal University, Shanghai 200062, China ) , Hao, Li (Department of Anatomy, Basic Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China ) , Xu, Ying (Department of Physiology, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China ) , Zhang, Zhi-xiong (Department of Physiology, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 368598 , 2014 , 1741-427x ,

    초록

    Overactivated microglia contribute to a variety of pathological conditions in the central nervous system. The major goal of the present study is to evaluate the potential suppressing effects of a new type of Ginko biloba extract, GBE50, on activated microglia which causes proinflammatory responses and to explore the underlying molecular mechanisms. Murine BV2 microglia cells, with or without pretreatmentof GBE50 at various concentrations, were activated by incubation with lipopolysaccharide (LPS). A series of biochemical and microscopic assays were performed to measure cell viability, cell morphology, release of tumor necrosis factor- α (TNF- α ) and interleukin-1 β (IL-1 β ), and signal transduction via the p38 MAPK and nuclear factor-kappa B (NF- κ B) p65 pathways. We found that GBE50 pretreatment suppressed LPS-induced morphological changes in BV2 cells. Moreover, GBE50 treatment significantly reduced the release of proinflammatory cytokines, TNF- α and IL-1 β , and inhibited the associated signal transduction through the p38 MAPK and NF- κ B p65 pathways. These results demonstrated the anti-inflammatory effect of GBE50 on LPS-activated BV2 microglia cells, and indicated that GBE50 reduced the LPS-induced proinflammatory TNF- α and IL-1 β release by inhibiting signal transduction through the NF- κ B p65 and p38 MAPK pathways. Our findings reveal, at least in part, the molecular basis underlying the anti-inflammatory effects of GBE50.

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  9. [해외논문]   The Alterations of IL-1Beta, IL-6, and TGF-Beta Levels in Hippocampal CA3 Region of Chronic Restraint Stress Rats after Electroacupuncture (EA) Pretreatment  

    Guo, Tianwei (School of Acupuncture-Moxibustion and Tui Na, Beijing University of Chinese Medicine, Beijing 100029, China ) , Guo, Zhuo (School of Acupuncture-Moxibustion and Tui Na, Beijing University of Chinese Medicine, Beijing 100029, China ) , Yang, Xinjing (School of Acupuncture-Moxibustion and Tui Na, Beijing University of Chinese Medicine, Beijing 100029, China ) , Sun, Lan (School of Acupuncture-Moxibustion and Tui Na, Beijing University of Chinese Medicine, Beijing 100029, China ) , Wang, Sihan (School of Acupuncture-Moxibustion and Tui Na, Beijing University of Chinese Medicine, Beijing 100029, China ) , Yingge, A. (School of Basic Medical Science, Inner Mongolia Medical University, Hohhot 010110, China ) , He, Xiaotian (Department of Tradition Chinese Medicine, Sanlitun Health Service Center, Beijing 100027, China ) , Ya, Tu (School of Acupuncture-Moxibustion and Tui Na, Beijing University of Chinese Medicine, Beijing 100029, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 369158 , 2014 , 1741-427x ,

    초록

    Immunological reactions induced by proinflammatory cytokines have been involved in the pathogenesis of depressive disorders. Recent studies showed that Electroacupuncture (EA) was able to reduce depressive symptoms; however, the underlying mechanism and its potential targets remain unknown. In the present study, we used a 21-day chronic restraint stress rats as a model to investigate how EA could alleviate depression. Open field test was carried out to evaluate the depressive symptoms at selected time points. At the end of study, immunohistochemistry (IHC) was performed to detect the expressions of IL-1beta, IL-6, and TGF-beta in hippocampal CA3 region. We found that chronic restraint stress significantly decreased behavioral activities, whereas EA stimulation at points Baihui (GV 20) and Yintang (GV 29) showed protective effect during the test period. In addition, the IL-1beta, IL-6, and TGF-beta increased in rats exposed to chronic restraint stress, while EA downregulated the levels of IL-1beta and IL-6. These findings implied that EA pretreatment could alleviate depression through modulating IL-1beta and IL-6 expression levels in hippocampal CA3 region.

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  10. [해외논문]   Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant  

    Fé (Laboratório de Tecnologia & Biotecnologia Farmacêutica (TecBioFar), Programa de Pós-graduação em Ciências Farmacêuticas (PPgCF), Universidade Federal do Rio Grande do Norte (UFRN), Rua General Cordeiro de Farias, s/n, Petrópolis, 59012-570 Natal, RN, Brazil ) , lix-Silva, Juliana (Laboratório de Farmacognosia, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Rua General Cordeiro de Farias, s/n, Petrópolis, 59012-570 Natal, RN, Brazil ) , Giordani, Raquel Brandt (Laboratório de Tecnologia & Biotecnologia Farmacêutica (TecBioFar), Programa de Pós-graduação em Ciências Farmacêuticas (PPgCF), Universidade Federal do Rio Grande do Norte (UFRN), Rua General Cordeiro de Farias, s/n, Petrópolis, 59012-570 Natal, RN, Brazil ) , da Silva-Jr, Arnó (Laboratório de Farmacognosia, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Rua General Cordeiro de Farias, s/n, Petr&oa) , bio Antonio , Zucolotto, Silvana Maria , Fernandes-Pedrosa, Matheus de Freitas
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 369204 , 2014 , 1741-427x ,

    초록

    Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “ bellyache bush, ” is a medicinal plant largely used throughout Africa and America. Several human and veterinary uses in traditional medicine are described for different parts and preparations based on this plant. However, critical reviews discussing emphatically its medicinal value are missing. This review aims to provide an up-to-date overview of the traditional uses, as well as the phytochemistry, pharmacology, and toxicity data of J. gossypiifolia species, in view of discussing its medicinal value and potential application in complementary and alternative medicine. Pharmacological studies have demonstrated significant action of different extracts and/or isolated compounds as antimicrobial, anti-inflammatory, antidiarrheal, antihypertensive, and anticancer agents, among others, supporting some of its popular uses. No clinical trial has been detected to date. Further studies are necessary to assay important folk uses, as well as to find new bioactive molecules with pharmacological relevance based on the popular claims. Toxicological studies associated with phytochemical analysis are important to understand the eventual toxic effects that could reduce its medicinal value. The present review provides insights for future research aiming for both ethnopharmacological validation of its popular use and its exploration as a new source of herbal drugs and/or bioactive natural products.

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