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Archives of pharmacal research : a publication of ... 23건

  1. [국내논문]   Comparison of Spectrophotometric, HPLC and Chemilumines­cence Methods for 3-Nitrotyrosine and Peroxynitrite Interaction  

    Turan Nilufer Nermin (Gazi University, Faculty of Pharmacy, Department of Pharmacology ) , Ark Mustafa (University of Mersin, Faculty of Medicine, Department of Pharmacology ) , Demiryurek Abdullah Tuncay (University of Gaziantep, Faculty of Medicine, Department of Pharmacology)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.3 ,pp. 358 - 363 , 2005 , 0253-6269 ,

    초록

    We have studied the interaction of 3-nitrotyrosine with peroxynitrite using three different methods; chemiluminescence, spectrophotometry and HPLC. Peroxynitrite-induced luminol or lucigenin chemiluminescence were significantly decreased by 3-nitrotyrosine, in concentration­dependent manners. The intensity of the peroxynitrite spectrum was also markedly reduced in the presence of 3-nitrotyrosine in the spectrophometric assay. However, there was no attenuation of the 3-nitrotyrosine signal in the HPLC assay after mixing with peroxynitrite. The interaction of 3-nitrotyrosine and hypochlorous acid (HOCI) was also studied via the chemilumines-cence assay, where the HOCI-induced responses were markedly inhibited by 3-nitrotyrosine. These results suggest that caution should be taken when studying the levels or interactions of 3-nitrotyrosine.

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  2. [국내논문]   Synthesis and Characterization of HPMC Derivatives as Novel Duodenum-Specific Coating Agents  

    Huang Yuan (Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University ) , Zheng ling Ii (Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University ) , Liu Jun (Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University ) , Zhang Zhi rong (Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.3 ,pp. 364 - 369 , 2005 , 0253-6269 ,

    초록

    HPMC (Hydroxypropyl methylcellulose) was chemically modified, using maleic anhydrides, to obtain pH-sensitive HPMCAM (Hydroxypropyl methylcellulose acetate maleate) polymers for use as novel duodenum-specific coating agents. The pharmaceutical properties of HPMCAM, such as film forming, acid values, pH-sensitive values, water vapor permeability, tensile strength and Tg, were investigated, and found to show good film forming properties. The pH­sensitive values were 3.0 to 3.7. In vitro results demonstrate that HPMCAM could completely suppress drug release within 2h in a simulated gastric fluid (pH 1.2) and rapidly release the drug in a simulated pathological duodenal fluid (pH 3.4). These results indicate that HPMCAM might be a useful material for a duodenum-specific drug delivery system.

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  3. [국내논문]   Development of New Reverse Micellar Microencapsulation Technique to Load Water-Soluble Drug into PLGA Microspheres   피인용횟수: 2

    Kim Hyun Joo (Department of Pharmaceutical Sciences, College of Pharmacy, Catholic University of Daegu ) , Cho Mi Hyun (Department of Pharmaceutical Sciences, College of Pharmacy, Catholic University of Daegu ) , Sah Hong Kee (Department of Pharmaceutical Sciences, College of Pharmacy, Catholic University of Daegu)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.28 no.3 ,pp. 370 - 375 , 2005 , 0253-6269 ,

    초록

    The objective of this study was to develop a new reverse micelle-based microencapsulation technique to load tetracycline hydrochloride into PLGA microspheres. To do so, a reverse micellar system was formulated to dissolve tetracycline hydrochloride and water in ethyl formate with the aid of cetyltrimethylammonium bromide. The resultant micellar solution was used to dissolve 0.3 to 0.75 g of PLGA, and microspheres were prepared following a modified solvent quenching technique. As a control experiment, the drug was encapsulated into PLGA microspheres via a conventional methylene chloride-based emulsion procedure. The micro­spheres were then characterized with regard to drug loading efficiency, their size distribution and morphology. The reverse micellar procedure led to the formation of free-flowing, spherical microspheres with the size mode of 88 ~m. When PLGA microspheres were prepared follow­ing the conventional methylene chloride-based procedure, most of tetracycline hydrochloride leached to the aqueous external phase: A maximal loading efficiency observed our experimental conditions was below $5\%$ . Their surfaces had numerous pores, while their internal architecture was honey-combed. In sharp contrast, the new reverse micellar encapsulation technique permitted the attainment of a maximal loading efficiency of 63.19 $\pm$ $0.64\%$ . Also, the microspheres had smooth and pore-free surfaces, and hollow cavities were absent from their internal matrices. The results of this study demonstrated that PLGA microspheres could be successfully prepared following the new reverse micellar encapsulation technique.

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