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IEEE transactions on bio-medical engineering 29건

  1. [해외논문]   Development of Novel 3-D Printed Scaffolds With Core-Shell Nanoparticles for Nerve Regeneration   SCI SCIE

    Se-Jun Lee (George Washington Univ., Washington, DC, USA ) , Wei Zhu (George Washington Univ., Washington, DC, USA ) , Heyburn, Lanier (Georgetown Univ., Washington, DC, USA ) , Nowicki, Margaret (George Washington Univ., Washington, DC, USA ) , Harris, Brent (Georgetown Univ., Washington, DC, USA) , Zhang, Lijie Grace
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 408 - 418 , 2017 , 0018-9294 ,

    초록

    A traumatic injury of peripheral nerves is serious clinical problem that may lead to major loss of nerve function, affecting quality of patient's life. Currently, nerve autograft is widely used to reconstruct the nerve gap. However, such surgical procedure suffers from many disadvantages including donor site morbidity and limited availability. In order to address these issues, neural tissue engineering has focused on the development of synthetic nerve scaffolds to support bridging a larger gap and improving nerve generation. For this purpose, we fabricated a novel 3-D biomimetic scaffold, which has tunable porous structure and embedded core-shell nanoparticles with sustained neurogenic factor delivery system, using stereolithography based 3-D printing and coaxial electrospraying techniques. Our results showed that scaffolds with larger porosity significantly improve PC-12 neural cell adhesion compared to ones with smaller porosity. Furthermore, scaffolds embedded with bovine serum albumin containing nanoparticles showed an enhancement in cell proliferation relative to bared control scaffolds. More importantly, confocal microscopy images illustrated that the scaffold with nerve growth factor nanoparticles greatly increased the length of neurites and directed neurite extension of PC-12 cells along the fiber. In addition, the 3-D printed nanocomposite scaffolds also improved the average neurite length of primary cortical neurons. The results in this study demonstrate the potential of this 3-D printed scaffold in improving neural cell function and nerve growth.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   On Quantitative Biomarkers of VNS Therapy Using EEG and ECG Signals   SCI SCIE

    Ravan, Maryam (LivaNova PLC (formerly Cyberonics Inc. the manufacturer of the AspireSR system) ) , Sabesan, Shivkumar (LivaNova PLC (formerly Cyberonics Inc. the manufacturer of the AspireSR system)) , D'Cruz, O'Neill
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 419 - 428 , 2017 , 0018-9294 ,

    초록

    Objective: The goal of this work is to objectively evaluate the effectiveness of neuromodulation therapies, specifically, Vagus nerve stimulation (VNS) in reducing the severity of seizures in patients with medically refractory epilepsy. Methods: Using novel quantitative features obtained from combination of electroencephalographic (EEG) and electrocardiographic (ECG) signals around seizure events in 16 patients who underwent implantation of closed-loop VNS therapy system, namely AspireSR, we evaluated if automated delivery of VNS at the time of seizure onset reduces the severity of seizures by reducing EEG spatial synchronization as well as the duration and magnitude of heart rate increase. Unsupervised classification was subsequently applied to test the discriminative ability and validity of these features to measure responsiveness to VNS therapy. Results: Results of application of this methodology to compare 105 pre-VNS treatment and 107 post-VNS treatment seizures revealed that seizures that were acutely stimulated using VNS had a reduced ictal spread as well as reduced impact on cardiovascular function compared to the ones that occurred prior to any treatment. Furthermore, application of an unsupervised fuzzy-c-mean classifier to evaluate the ability of the combined EEG–ECG based features to classify pre and post-treatment seizures achieved a classification accuracy of 85.85%. Conclusion: These results indicate the importance of timely delivery of VNS to reduce seizure severity and thus help achieve better seizure control for patients with epilepsy. Significance: The proposed set of quantitative features could be used as potential biomarkers for predicting long-term response to VNS therapy.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  3. [해외논문]   See It With Your Own Eyes: Markerless Mobile Augmented Reality for Radiation Awareness in the Hybrid Room   SCI SCIE

    Loy Rodas, Nicolas (ICubeUniversity of Strasbourg, CNRS, IHU Strasbourg ) , Barrera, Fernando (ICubeUniversity of Strasbourg, CNRS, IHU Strasbourg) , Padoy, Nicolas
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 429 - 440 , 2017 , 0018-9294 ,

    초록

    Goal: We present an approach to provide awareness to the harmful ionizing radiation generated during X-ray-guided minimally invasive procedures. Methods: A hand-held screen is used to display directly in the user's view information related to radiation safety in a mobile augmented reality (AR) manner. Instead of using markers, we propose a method to track the observer's viewpoint, which relies on the use of multiple RGB-D sensors and combines equipment detection for tracking initialization with a KinectFusion-like approach for frame-to-frame tracking. Two of the sensors are ceiling-mounted and a third one is attached to the hand-held screen. The ceiling cameras keep an updated model of the room's layout, which is used to exploit context information and improve the relocalization procedure. Results: The system is evaluated on a multicamera dataset generated inside an operating room (OR) and containing ground-truth poses of the AR display. This dataset includes a wide variety of sequences with different scene configurations, occlusions, motion in the scene, and abrupt viewpoint changes. Qualitative results illustrating the different AR visualization modes for radiation awareness provided by the system are also presented. Conclusion: Our approach allows the user to benefit from a large AR visualization area and permits to recover from tracking failure caused by vast motion or changes in the scene just by looking at a piece of equipment. Significance: The system enables the user to see the 3-D propagation of radiation, the medical staff's exposure, and/or the doses deposited on the patient's surface as seen through his own eyes.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   IntSIM: An Integrated Simulator of Next-Generation Sequencing Data   SCI SCIE

    Yuan, Xiguo (School of Computer Science and TechnologyXidian University ) , Zhang, Junying (School of Computer Science and TechnologyXidian University) , Yang, Liying
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 441 - 451 , 2017 , 0018-9294 ,

    초록

    Objective: Next-generation sequencing data has been widely used for DNA variant discovery and tumor study through computational tools. Effective simulation of such data with many realistic features is very necessary for testing existing tools and guiding the development of new tools. Methods: We present an integrated simulation system, IntSIM, to simulate common DNA variants and to generate sequencing reads for mixture genomes. IntSIM has three novel features in comparison with other simulation programs: 1) it is able to simulate both germline and somatic variants in the same sequence, 2) it deals with tumor purity so as to generate reads corresponding to heterogeneous genomes and also produce tumor-normal matched samples, and 3) it simulates correlations among SNPs, among CNVs/CNAs based on HMM models trained from real sequencing genomes, and can simulates broad and focal CNV/CNA events. Results: The simulation data of IntSIM can reflect characteristics observed from real data and are consistent with input parameters. The IntSIM software package is freely available at http://intsim.sourceforge.net/ . Conclusion: Based on a great number of experiments, IntSIM performs better than other program for some scenarios, such as simulation of heterozygous SNPs, CNVs/CNAs, and can achieve some functions that other programs cannot achieve. Significance: Simulation with IntSIM can be expected to evaluate performance of methods in detecting various types of variants, analyzing tumor samples, and especially providing a realistic assessment of effect of tumor purity on identification of somatic mutations.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  5. [해외논문]   Channel Modeling of Miniaturized Battery-Powered Capacitive Human Body Communication Systems   SCI SCIE

    Park, Jiwoong , Garudadri, Harinath , Mercier, Patrick P.
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 452 - 462 , 2017 , 0018-9294 ,

    초록

    Objective: The purpose of this contribution is to estimate the path loss of capacitive human body communication (HBC) systems under practical conditions. Methods: Most prior work utilizes large grounded instruments to perform path loss measurements, resulting in overly optimistic path loss estimates for wearable HBC devices. In this paper, small battery-powered transmitter and receiver devices are implemented to measure path loss under realistic assumptions. A hybrid electrostatic finite element method simulation model is presented that validates measurements and enables rapid and accurate characterization of future capacitive HBC systems. Results: Measurements from form-factor-accurate prototypes reveal path loss results between 31.7 and 42.2 dB from 20 to 150 MHz. Simulation results matched measurements within 2.5 dB. Comeasurements using large grounded benchtop vector network analyzer (VNA) and large battery-powered spectrum analyzer (SA) underestimate path loss by up to 33.6 and 8.2 dB, respectively. Measurements utilizing a VNA with baluns, or large battery-powered SAs with baluns still underestimate path loss by up to 24.3 and 6.7 dB, respectively. Conclusion: Measurements of path loss in capacitive HBC systems strongly depend on instrumentation configurations. It is thus imperative to simulate or measure path loss in capacitive HBC systems utilizing realistic geometries and grounding configurations. Significance: HBC has a great potential for many emerging wearable devices and applications; accurate path loss estimation will improve system-level design leading to viable products.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Skin-Potential Variation Insensitive Dry Electrodes for ECG Recording   SCI SCIE

    Pei, Weihua (State Key Laboratory on Integrated OptoelectronicsCAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of SemiconductorsChinese Academy of Sciences ) , Zhang, He (State Key Laboratory on Integrated OptoelectronicsCAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of SemiconductorsChinese Academy of Sciences ) , Wang, Yijun (State Key Laboratory on Integrated OptoelectronicsCAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of SemiconductorsChinese Academy of Sciences ) , Guo, Xuhong (State Key Laboratory on Integrated OptoelectronicsCAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of SemiconductorsChinese Academy of Sciences ) , Xing, Xiao (State Key Laboratory on Integrated OptoelectronicsCAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of SemiconductorsChinese Academy of Sciences ) , Huang, Yong (State Key Laboratory on Integrated OptoelectronicsCAS Center for Excellence in Brain Science and Intelligence Techn) , Xie, Yuxing , Yang, Xiaowei , Chen, Hongda
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 463 - 470 , 2017 , 0018-9294 ,

    초록

    Objective: A skin-potential variation (SPV) insensitive dry electrode is developed to remove the interference of SPV. Methods: Based on a conventional microneedles array-based electrode, a layer of Parylene membrane is coated at the root of microneedles to insulate the electrode from the corneum layer. Only tips of the needles are exposed to make it can contact with the stratum germinativum layer directly. Results: As a result, skin potential will not be coupled into the recording electrode. Thus, SPV will not influence the biopotential recording in the dynamic state. Conclusion: The proposed electrode is potential for a device which is insensitive to the motion noise source from SPV. Significance: It paves the way for applications of the proposed dry electrode in the wearable technology which require strong anti-motion interference ability.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  7. [해외논문]   An Enhanced Adaptive Filtering Method for Suppressing Cardiopulmonary Resuscitation Artifact   SCI SCIE

    Gong, Yushun (School of Biomedical EngineeringThird Military Medical University ) , Gao, Peng (School of Biomedical EngineeringThird Military Medical University ) , Wei, Liang (School of Biomedical EngineeringThird Military Medical University ) , Dai, Chenxi (School of Biomedical EngineeringThird Military Medical University ) , Zhang, Lei (Department of EmergencySouthwest HospitalThird Military Medical University) , Li, Yongqin
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 471 - 478 , 2017 , 0018-9294 ,

    초록

    Cardiopulmonary resuscitation (CPR) must be interrupted for reliable rhythm analysis in current automatic external defibrillators because of artifacts produced by chest compressions. However, interruptions in CPR adversely affect the restoration of spontaneous circulation and survival. Suppressing CPR artifacts by digital signal processing techniques is a promising method to enable rhythm analysis during chest compressions, which would eliminate CPR interruptions for rhythm analysis. Although numerous methods have been developed to suppress CPR artifacts, the accuracy of rhythm analysis is still inadequate due to the residual artifact components in the filtered signal. This study proposes an enhanced adaptive filtering method to suppress CPR artifacts. A total of 183 shockable and 453 nonshockable segments of ECG signal, together with CPR-related reference signal, were extracted from 233 out of hospital cardiac arrest patients. The method was optimized on a training set with 85 shockable and 211 nonshockable segments, and evaluated on a testing set with 98 shockable and 242 nonshockable segments. Compared with artifact corrupted ECG signals, the signal-to-noise ratio (SNR) increased from −9.8 ± 12.5 to 11.2 ± 11.8 dB, and the accuracy was improved from 74.1% to 92.0% after filtering with the proposed method. Compared with the traditional adaptive filter, the SNR was improved by 1.7 dB and the accuracy was improved by 5.6 points. These results indicated that the proposed method could effectively suppress the chest compression related artifacts and improve the accuracy of rhythm analysis during uninterrupted CPR.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  8. [해외논문]   Event Recognition for Contactless Activity Monitoring Using Phase-Modulated Continuous Wave Radar   SCI SCIE

    Forouzanfar, Mohamad (Sch. of Electr. Eng. & Comput. Sci., Univ. of Ottawa, Ottawa, ON, Canada ) , Mabrouk, Mohamed (Dept. of Syst. & Comput. Eng., Carleton Univ., Ottawa, ON, Canada ) , Rajan, Sreeraman (Sch. of Electr. Eng. & Comput. Sci., Univ. of Ottawa, Ottawa, ON, Canada ) , Bolic, Miodrag (Sch. of Electr. Eng. & Comput. Sci., Univ. of Ottawa, Ottawa, ON, Canada ) , Dajani, Hilmi R. (Sch. of Electr. Eng. & Comput. Sci., Univ. of Ottawa, Ottawa, ON, Canada) , Groza, Voicu Z.
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 479 - 491 , 2017 , 0018-9294 ,

    초록

    Objectives: The use of remote sensing technologies such as radar is gaining popularity as a technique for contactless detection of physiological signals and analysis of human motion. This paper presents a methodology for classifying different events in a collection of phase modulated continuous wave radar returns. The primary application of interest is to monitor inmates where the presence of human vital signs amidst different, interferences needs to be identified. Methods: A comprehensive set of features is derived through time and frequency domain analyses of the radar returns. The Bhattacharyya distance is used to preselect the features with highest class separability as the possible candidate features for use in the classification process. The uncorrelated linear discriminant analysis is performed to decorrelate, denoise, and reduce the dimension of the candidate feature set. Linear and quadratic Bayesian classifiers are designed to distinguish breathing, different human motions, and nonhuman motions. The performance of these classifiers is evaluated on a pilot dataset of radar returns that contained different events including breathing, stopped breathing, simple human motions, and movement of fan and water. Results: Our proposed pattern classification system achieved accuracies of up to 93% in stationary subject detection, 90% in stop-breathing detection, and 86% in interference detection. Conclusion: Our proposed radar pattern recognition system was able to accurately distinguish the predefined events amidst interferences. Significance: Besides inmate monitoring and suicide attempt detection, this paper can be extended to other radar applications such as home-based monitoring of elderly people, apnea detection, and home occupancy detection.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Characterization of Axonal Spikes in Cultured Neuronal Networks Using Microelectrode Arrays and Microchannel Devices   SCI SCIE

    Hong, Nari (Department of Bio and Brain EngineeringKorea Advanced Institute of Science and Technology ) , Joo, Sunghoon (Department of Bio and Brain EngineeringKorea Advanced Institute of Science and Technology) , Nam, Yoonkey
    IEEE transactions on bio-medical engineering v.64 no.2 ,pp. 492 - 498 , 2017 , 0018-9294 ,

    초록

    Objective: Axonal propagation has a pivotal role in information processing in the brain. However, there has been little experimental study due to the difficulty of isolation of axons and recording their signals. Here, we developed dual chamber neuronal network interconnected with axons by integrating microchannel devices with microelectrode arrays (MEAs) to investigate axonal signals in developmental stage. Methods: The device was composed of two chambers and microchannels between them, and hippocampal neurons were cultured in both chambers. Neuronal activity was recorded for four weeks. Results: Large axonal signal was detected in microchannels, which were 137.0 +/- 8.5 mu V at 14 days in vitro (DIV). It was significantly larger than those in chambers with a similar range of signal-to-noise ratio. Detection efficiency of axonal spikes was analyzed by calculating the number of active electrodes over time. We found that active electrodes were detected earlier and their number increased faster in microchannels than those in chambers. Finally, we estimated the axonal conduction velocity and 73% of axons had the velocity in range of 0.2-0.5 m/s at 14 DIV. By estimating the velocity over the cultivation period, we observed that axonal conduction velocity increased linearly over time. Conclusion: Using MEAs and microchannel devices, we successfully detected large axonal signals and analyzed their detection efficiency and conduction velocity. We first showed the gradual increase in conduction velocity depending on cultivation days. Significance: The developed microchannel device integrated MEA may be applicable for the studies of axonal conduction in cultured neuronal networks.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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