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Human brain mapping 27건

  1. [해외논문]   The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype  

    Rabellino, Daniela (Department of Psychiatry, University of Western Ontario, London, Ontario, Canada) , Densmore, Maria (Department of Psychiatry, University of Western Ontario, London, Ontario, Canada) , Thé (Department of Psychiatry, University of Western Ontario, London, Ontario, Canada) , berge, Jean (Mood Disorders Program, St. Joseph's Healthcare, Hamilton, Ontario, Canada) , McKinnon, Margaret C. (Department of Psychiatry, University of Western Ontario, London, Ontario, Canada) , Lanius, Ruth A.
    Human brain mapping v.39 no.8 ,pp. 3354 - 3374 , 2018 , 1065-9471 ,

    초록

    Abstract The cerebellum plays a key role not only in motor function but also in affect and cognition. Although several psychopathological disorders have been associated with overall cerebellar dysfunction, it remains unclear whether different regions of the cerebellum contribute uniquely to psychopathology. Accordingly, we compared seed‐based resting‐state functional connectivity of the anterior cerebellum (lobule IV–V), of the posterior cerebellum (Crus I), and of the anterior vermis across posttraumatic stress disorder (PTSD; n = 65), its dissociative subtype (PTSD + DS; n = 37), and non‐trauma‐exposed healthy controls (HC; n = 47). Here, we observed decreased functional connectivity of the anterior cerebellum and anterior vermis with brain regions involved in somatosensory processing, multisensory integration, and bodily self‐consciousness (temporo‐parietal junction, postcentral gyrus, and superior parietal lobule) in PTSD + DS as compared to PTSD and HC. Moreover, the PTSD + DS group showed increased functional connectivity of the posterior cerebellum with cortical areas related to emotion regulation (ventromedial prefrontal and orbito‐frontal cortex, subgenual anterior cingulum) as compared to PTSD. By contrast, PTSD showed increased functional connectivity of the anterior cerebellum with cortical areas associated with visual processing (fusiform gyrus), interoceptive awareness (posterior insula), memory retrieval, and contextual processing (hippocampus) as compared to HC. Finally, we observed decreased functional connectivity between the posterior cerebellum and prefrontal regions involved in emotion regulation, in PTSD as compared to HC. These findings not only highlight the crucial role of each cerebellar region examined in the psychopathology of PTSD but also reveal unique alterations in functional connectivity distinguishing the dissociative subtype of PTSD versus PTSD.

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  2. [해외논문]   Advanced MR diffusion imaging and chemotherapy‐related changes in cerebral white matter microstructure of survivors of childhood bone and soft tissue sarcoma?  

    Sleurs, Charlotte (Department of Pediatrics, University Hospitals Leuven, UZ Leuven, Belgium) , Lemiere, Jurgen (Department of Pediatrics, University Hospitals Leuven, UZ Leuven, Belgium) , Christiaens, Daan (Centre for the Developing Brain, King's College London, London, United Kingdom) , Billiet, Thibo (Imaging Biomarker Experts, Icometrix, Leuven, Belgium) , Peeters, Ronald (Department of Radiology, University Hospitals Leuven, UZ Leuven, Belgium) , Sunaert, Stefan (Department of Radiology, University Hospitals Leuven, UZ Leuven, Belgium) , Uyttebroeck, Anne (Department of Pediatrics, University Hospitals Leuven, UZ Leuven, Belgium) , Deprez, Sabine (Department of Radiology, University Hospitals Leuven, UZ Leuven, Belgium)
    Human brain mapping v.39 no.8 ,pp. 3375 - 3387 , 2018 , 1065-9471 ,

    초록

    Abstract With the increase of survival rates of pediatric cancer patients, the number of children facing potential cognitive sequelae has grown. Previous adult studies suggest that white matter (WM) microstructural changes may contribute to cognitive impairment. This study aims to investigate WM microstructure in childhood bone and soft tissue sarcoma. Differences in (micro‐)structure can be investigated using diffusion MRI (dMRI). The typically used diffusion tensor model (DTI) assumes Gaussian diffusion, and lacks information about fiber populations. In this study, we compare WM structure of childhood bone and soft tissue sarcoma survivors ( n = 34) and matched controls ( n = 34), combining typical and advanced voxel‐based models (DTI and NODDI model, respectively), as well as recently developed fixel‐based models (for estimations of intra‐voxel differences, apparent fiber density [AFD] and fiber cross‐section [FC]). Parameters with significant findings were compared between treatments, and correlated with subscales of the WAIS‐IV intelligence test, age at diagnosis, age at assessment and time since diagnosis. We encountered extensive regions showing lower fractional anisotropy, overlapping with both significant NODDI parameters and fixel‐based parameters. In contrast to these diffuse differences, the fixel‐based measure of AFD was reduced in the cingulum and corpus callosum only. Furthermore, AFD of the corpus callosum was significantly predicted by chemotherapy treatment and correlated positively with time since diagnosis, visual puzzles and similarities task scores. This study suggests altered WM structure of childhood bone and soft tissue sarcoma survivors. We conclude global chemotherapy‐related changes, with particular vulnerability of centrally located WM bundles. Finally, such differences could potentially recover after treatment.

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  3. [해외논문]   Altered intra‐ and inter‐network functional coupling of resting‐state networks associated with motor dysfunction in stroke  

    Zhao, Zhiyong (Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, 200062, China) , Wu, Jie (Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, 200062, China) , Fan, Mingxia (Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, 200062, China) , Yin, Dazhi (Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China) , Tang, Chaozheng (Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai, 200040, China) , Gong, Jiayu (Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, 200062, China) , Xu, Guojun , Gao, Xinjie , Yu, Qiurong , Yang, Hao , Sun, Limin , Jia, Jie
    Human brain mapping v.39 no.8 ,pp. 3388 - 3397 , 2018 , 1065-9471 ,

    초록

    Abstract Motor functions are supported through functional integration across the extended motor system network. Individuals following stroke often show deficits on motor performance requiring coordination of multiple brain networks; however, the assessment of connectivity patterns after stroke was still unclear. This study aimed to investigate the changes in intra‐ and inter‐network functional connectivity (FC) of multiple networks following stroke and further correlate FC with motor performance. Thirty‐three left subcortical chronic stroke patients and 34 healthy controls underwent resting‐state functional magnetic resonance imaging. Eleven resting‐state networks were identified via independent component analysis (ICA). Compared with healthy controls, the stroke group showed abnormal FC within the motor network (MN), visual network (VN), dorsal attention network (DAN), and executive control network (ECN). Additionally, the FC values of the ipsilesional inferior parietal lobule (IPL) within the ECN were negatively correlated with the Fugl‐Meyer Assessment (FMA) scores (hand + wrist). With respect to inter‐network interactions, the ipsilesional frontoparietal network (FPN) decreased FC with the MN and DAN; the contralesional FPN decreased FC with the ECN, but it increased FC with the default mode network (DMN); and the posterior DMN decreased FC with the VN. In sum, this study demonstrated the coexistence of intra‐ and inter‐network alterations associated with motor‐visual attention and high‐order cognitive control function in chronic stroke, which might provide insights into brain network plasticity following stroke.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   The anticipation and outcome phases of reward and loss processing: A neuroimaging meta‐analysis of the monetary incentive delay task  

    Oldham, Stuart (Brain and Mental Health Research Hub, School of Psychological Sciences and the Monash Institute of Cognitive and Clinical Neurosciences (MICCN), Monash University, Clayton, Victoria, Australia) , Murawski, Carsten (Department of Finance, The University of Melbourne, Parkville, Victoria, Australia) , Fornito, Alex (Brain and Mental Health Research Hub, School of Psychological Sciences and the Monash Institute of Cognitive and Clinical Neurosciences (MICCN), Monash University, Clayton, Victoria, Australia) , Youssef, George (Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia) , Yü (Brain and Mental Health Research Hub, School of Psychological Sciences and the Monash Institute of Cognitive and Clinical Neurosciences (MICCN), Monash University, Clayton, Victoria, Australia) , cel, Murat (Brain and Mental Health Research Hub, School of P) , Lorenzetti, Valentina
    Human brain mapping v.39 no.8 ,pp. 3398 - 3418 , 2018 , 1065-9471 ,

    초록

    Abstract The processing of rewards and losses are crucial to everyday functioning. Considerable interest has been attached to investigating the anticipation and outcome phases of reward and loss processing, but results to date have been inconsistent. It is unclear if anticipation and outcome of a reward or loss recruit similar or distinct brain regions. In particular, while the striatum has widely been found to be active when anticipating a reward, whether it activates in response to the anticipation of losses as well remains ambiguous. Furthermore, concerning the orbitofrontal/ventromedial prefrontal regions, activation is often observed during reward receipt. However, it is unclear if this area is active during reward anticipation as well. We ran an Activation Likelihood Estimation meta‐analysis of 50 fMRI studies, which used the Monetary Incentive Delay Task (MIDT), to identify which brain regions are implicated in the anticipation of rewards, anticipation of losses, and the receipt of reward. Anticipating rewards and losses recruits overlapping areas including the striatum, insula, amygdala and thalamus, suggesting that a generalised neural system initiates motivational processes independent of valence. The orbitofrontal/ventromedial prefrontal regions were recruited only during the reward outcome, likely representing the value of the reward received. Our findings help to clarify the neural substrates of the different phases of reward and loss processing, and advance neurobiological models of these processes.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Neural correlates of processing emotional prosody in unipolar depression  

    Koch, Katharina (Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany) , Stegmaier, Sophia (Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany) , Schwarz, Lena (Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany) , Erb, Michael (Department of Biomedical Resonance, University of Tuebingen, Tuebingen, Germany) , Reinl, Maren (Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany) , Scheffler, Klaus (Department of Biomedical Resonance, University of Tuebingen, Tuebingen, Germany) , Wildgruber, Dirk (Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany) , Ethofer, Thomas (Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany)
    Human brain mapping v.39 no.8 ,pp. 3419 - 3427 , 2018 , 1065-9471 ,

    초록

    Abstract Major depressive disorder (MDD) is characterized by a biased emotion perception. In the auditory domain, MDD patients have been shown to exhibit attenuated processing of positive emotions expressed by speech melody (prosody). So far, no neuroimaging studies examining the neural basis of altered processing of emotional prosody in MDD are available. In this study, we addressed this issue by examining the emotion bias in MDD during evaluation of happy, neutral, and angry prosodic stimuli on a five‐point Likert scale during functional magnetic resonance imaging (fMRI). As expected, MDD patients rated happy prosody less intense than healthy controls (HC). At neural level, stronger activation in the middle superior temporal gyrus (STG) and the amygdala was found in all participants when processing emotional as compared to neutral prosody. MDD patients exhibited an increased activation of the amygdala during processing prosody irrespective of valence while no significant differences between groups were found for the STG, indicating that altered processing of prosodic emotions in MDD occurs rather within the amygdala than in auditory areas. Concurring with the valence‐specific behavioral effect of attenuated evaluation of positive prosodic stimuli, activation within the left amygdala of MDD patients correlated with ratings of happy, but not neutral or angry prosody. Our study provides first insights in the neural basis of reduced experience of positive information and an abnormally increased amygdala activity during prosody processing.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Effects of SYN1Q555X mutation on cortical gray matter microstructure  

    Cabana, Jean‐ (Centre Hospitalier de l'Université) , Franç (de Montréal (CHUM), Montréal, Québec ) , ois (Centre Hospitalier de l'Université) , Gilbert, Guillaume (de Montréal (CHUM), Montréal, Québec ) , Lé (Centre Hospitalier de l'Université) , tourneau‐ (de Montréal (CHUM), Montréal, Québec ) , Guillon, Laurent (Université) , Safi, Dima (du Québec à) , Rouleau, Isabelle (Trois‐Rivières (UQTR), Trois‐Rivières, Québec ) , Cossette, Patrick (Centre de Recherche du CHUM (CRCHUM), Montréal, Québec ) , Nguyen, Dang Khoa (Centre Hospitalier de l'Université)
    Human brain mapping v.39 no.8 ,pp. 3428 - 3448 , 2018 , 1065-9471 ,

    초록

    Abstract A new Q555X mutation on the SYN1 gene was recently found in several members of a family segregating dyslexia, epilepsy, and autism spectrum disorder. To describe the effects of this mutation on cortical gray matter microstructure, we performed a surface‐based group study using novel diffusion and quantitative multiparametric imaging on 13 SYN1 Q555X mutation carriers and 13 age‐ and sex‐matched controls. Specifically, diffusion kurtosis imaging (DKI) and neurite orientation and dispersion and density imaging (NODDI) were used to analyze multi‐shell diffusion data and obtain parametric maps sensitive to tissue structure, while quantitative metrics sensitive to tissue composition (T1, T2* and relative proton density [PD]) were obtained from a multi‐echo variable flip angle FLASH acquisition. Results showed significant microstructural alterations in several regions usually involved in oral and written language as well as dyslexia. The most significant changes in these regions were lowered mean diffusivity and increased fractional anisotropy. This study is, to our knowledge, the first to successfully use diffusion imaging and multiparametric mapping to detect cortical anomalies in a group of subjects with a well‐defined genotype linked to language impairments, epilepsy and autism spectrum disorder (ASD).

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Novel in silico multivariate mapping of intrinsic and anticorrelated connectivity to neurocognitive functional maps supports the maturational hypothesis of ADHD  

    de Lacy, Nina (Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA) , Kodish, Ian (Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA) , Rachakonda, Srinivas (Mind Research Network, Albuquerque, NM, 87106) , Calhoun, Vince D. (Mind Research Network, Albuquerque, NM, 87106)
    Human brain mapping v.39 no.8 ,pp. 3449 - 3467 , 2018 , 1065-9471 ,

    초록

    Abstract From childhood to adolescence, strengthened coupling in frontal, striatal and parieto‐temporal regions associated with cognitive control, and increased anticorrelation between task‐positive and task‐negative circuits, subserve the reshaping of behavior. ADHD is a common condition peaking in adolescence and regressing in adulthood, with a wide variety of cognitive control deficits. Alternate hypotheses of ADHD emphasize lagging circuitry refinement versus categorical differences in network function. However, quantifying the individual circuit contributions to behavioral findings, and relative roles of maturational versus categorical effects, is challenging in vivo or in meta‐analyses using task‐based paradigms within the same pipeline, given the multiplicity of neurobehavioral functions implicated. To address this, we analyzed 46 positively‐correlated and anticorrelated circuits in a multivariate model in resting‐state data from 504 age‐ and gender‐matched youth, and created a novel in silico method to map individual quantified effects to reverse inference maps of 8 neurocognitive functions consistently implicated in ADHD, as well as dopamine and hyperactivity. We identified only age‐ and gender‐related effects in intrinsic connectivity, and found that maturational refinement of circuits in youth with ADHD occupied 3‐10x more brain locations than in typical development, with the footprint, effect size and contribution of individual circuits varying substantially. Our analysis supports the maturational hypothesis of ADHD, suggesting lagging connectivity reorganization within specific subnetworks of fronto‐parietal control, ventral attention, cingulo‐opercular, temporo‐limbic and cerebellar sub‐networks contribute across neurocognitive findings present in this complex condition. We present the first analysis of anti‐correlated connectivity in ADHD and suggest new directions for exploring residual and non‐responsive symptoms.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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