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Clinical immunology : the official journal of the ... 49건

  1. [해외논문]   Systemic manifestations of primary SjOgren's syndrome in the NOD.B10Sn-H2 b /J mouse model   SCI SCIE SCOPUS

    Kiripolsky, Jeremy (Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA ) , Shen, Long (Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, China ) , Liang, Yichen (Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA ) , Li, Alisa (Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA ) , Suresh, Lakshmanan (Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA ) , Lian, Yun (Microarray Core Facility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA ) , Li, Quan-Zhen (Microarray Core Facility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA ) , Gaile, Daniel P. (Department of Biostatistics, School of Public Health and Health Professions, University of Buffalo, The State University of New York, 3435 Main Street, 718 Kimball Tower, Buffalo, NY 14214, USA ) , Kramer, Jill M. (Department of Oral Biology, Sch)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 225 - 232 , 2017 , 1521-6616 ,

    초록

    Abstract Animal models that recapitulate human disease are crucial for the study of SjOgren's Syndrome (SS). While several SS mouse models exist, there are few primary SS (pSS) models that mimic systemic disease manifestations seen in humans. Similar to pSS patients, NOD.B10Sn- H2 b /J (NOD.B10) mice develop exocrine gland disease and anti-nuclear autoantibodies. However, the disease kinetics and spectrum of extra-glandular disease remain poorly characterized in this model. Our objective was to characterize local and systemic SS manifestations in depth in NOD.B10 female mice at early and late disease time points. To this end, sera, exocrine tissue, lung, and kidney were analyzed. NOD.B10 mice have robust lymphocytic infiltration of salivary and lacrimal tissue. In addition, they exhibit significant renal and pulmonary inflammation. We identified numerous autoantibodies, including those directed against salivary proteins. In conclusion, the NOD.B10 model recapitulates both local and systemic pSS disease and represents an excellent model for translational studies. Highlights NOD.B10 mice represent an excellent model for primary SjOgren's syndrome (pSS). NOD.B10 females exhibit sialadenitis and dacryoadenitis and lose salivary flow. NOD.B10 mice also show extra-glandular manifestations of pSS. Similar to some pSS patients, NOD.B10 females show pulmonary and renal inflammation. Novel SS autoantibodies are elevated in sera from NOD.B10 mice.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Abnormalities in CD57+ cytotoxic T cells and Vδ1+ γδT cells in subclinical celiac disease in childhood are affected by cytomegalovirus. The Generation R Study   SCI SCIE SCOPUS

    Jansen, M.A.E. (The Generation R Study Group, Erasmus MC-Sophia, Rotterdam, The Netherlands ) , van den Heuvel, D. (Department of Immunology, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands ) , Jaddoe, V.W.V. (The Generation R Study Group, Erasmus MC-Sophia, Rotterdam, The Netherlands ) , van Zelm, M.C. (Department of Immunology, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands ) , Moll, H.A. (Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 233 - 239 , 2017 , 1521-6616 ,

    초록

    Abstract Celiac disease (CD) is a digestive and autoimmune disorder driven by an immune response to modified gluten peptides. Affected intestines show infiltrates of various T-cell and NK-cell subsets. It is currently unclear if individuals with subclinical CD have systemic abnormalities in immune cells. We here studied whether subclinical CD is associated with changes in blood CD57-expressing and Vδ1-expressing lymphocytes in children, and whether cytomegalovirus (CMV) infection modifies this association. Included were 1068 children from the Generation R Study. Serum Immunoglobulin G (IgG) levels against CMV were measured by ELISA; Tissue transglutaminase type 2 antibody (TG2A) levels with fluorescence enzyme immunoassay (FEIA). Duodenal biopsies, additional Human Leukocyte Antigen (HLA) DQ 2.2, 2.5 and 8 and endomysial antibody (EMA) typing were performed in TG2A positive children. Subclinical CD cases ( n = 12) had 1.8 fold (95% CI 1.06; 3.1) fewer Vδ1+ T cells which was predominantly observed in CMV seronegative children (p-interaction 0.02), and 2.7 fold (95% CI 1.25; 5.99) more CD57+ T cells than HLA DQ2/-DQ8 positive controls ( n = 339). Hence, children with subclinical CD have alterations in specific blood T cell subsets that are linked to viral pathology. The observed interaction effect between subclinical CD and CMV may contribute to the understanding of disease pathogenesis. Highlights Blood CD57+ T cells are increased in subclinical celiac disease (CD) in childhood. In contrast, blood Vδ1+ cells are decreased, especially in CMV seronegative children. Chronic immune activation or immunosenescence may be involved in CD pathogenesis. Recruitment of Vδ1+ cells to the intestinal epithelium may appear prior to disease onset.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice   SCI SCIE SCOPUS

    Ogura, Mineko (Department of Immunobiology, Yale University, New Haven, CT, United States ) , Deng, Songyan (Department of Immunobiology, Yale University, New Haven, CT, United States ) , Preston-Hurlburt, Paula (Department of Immunobiology, Yale University, New Haven, CT, United States ) , Ogura, Hideki (Department of Immunobiology, Yale University, New Haven, CT, United States ) , Shailubhai, Kunwar (Tiziana Life Sciences, R&D Center, 3805 Old Easton Road, Doylestown, PA 18902, United States ) , Kuhn, Chantal (Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, United States ) , Weiner, Howard L. (Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, United States ) , Herold, Kevan C. (Department of Immunobiology, Yale University, New Haven, CT, United States)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 240 - 246 , 2017 , 1521-6616 ,

    초록

    Abstract Oral administration of biologics may be a feasible approach for immune therapy that improves drug safety and potentiates mechanisms of tolerance at mucosal barriers. We tested the ability of a fully human non-FcR binding anti-CD3 mAb, foralumab, to prevent skin xenograft rejection in mice with human immune systems. At an intragastric dose of 15μg, the drug could transit through the small bowel. Serum absorption and binding of lymphoid cells was seen and proliferative responses of splenic CD8+ T cells to mitogen were reduced. Five consecutive daily doses, then weekly dosing led to indefinite graft acceptance without depletion of peripheral T cells. Proliferative and cytokine responses to activation of splenocytes with PHA were reduced. The serum levels of IL-10 but not TNF were increased 6days after application of the skin graft. Oral treatment with anti-CD3 mAb may represent a feasible approach for immune modulation. Highlights In humanized mice, intragastric anti-CD3 mAb prevents xenograft rejection. Anti-CD3 mAb passes through the stomach and small bowel and can be detected in the serum. Intragastric anti-CD3 mAb affects CD8+ T cell proliferation in the spleen and cytokine production. Anti-CD3 mAb treatment induces IL-10 release.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Diagnostic dilemma: ALPS versus Evans syndrome   SCI SCIE SCOPUS

    Li, Evan (Department of Medicine, Section of Allergy and Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States ) , Grimes, Amanda B. (Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States ) , Rider, Nicholas L. (Department of Pediatrics, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States ) , Mahoney, Donald H. (Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States ) , Fleisher, Thomas A. (Department of Laboratory Medicine, Immunology Service, National Institutes of Health Clinical Center, Bethesda, MD, United States ) , Shearer, William T. (Department of Pediatrics, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 247 - 248 , 2017 , 1521-6616 ,

    초록

    Abstract Oral administration of biologics may be a feasible approach for immune therapy that improves drug safety and potentiates mechanisms of tolerance at mucosal barriers. We tested the ability of a fully human non-FcR binding anti-CD3 mAb, foralumab, to prevent skin xenograft rejection in mice with human immune systems. At an intragastric dose of 15μg, the drug could transit through the small bowel. Serum absorption and binding of lymphoid cells was seen and proliferative responses of splenic CD8+ T cells to mitogen were reduced. Five consecutive daily doses, then weekly dosing led to indefinite graft acceptance without depletion of peripheral T cells. Proliferative and cytokine responses to activation of splenocytes with PHA were reduced. The serum levels of IL-10 but not TNF were increased 6days after application of the skin graft. Oral treatment with anti-CD3 mAb may represent a feasible approach for immune modulation. Highlights In humanized mice, intragastric anti-CD3 mAb prevents xenograft rejection. Anti-CD3 mAb passes through the stomach and small bowel and can be detected in the serum. Intragastric anti-CD3 mAb affects CD8+ T cell proliferation in the spleen and cytokine production. Anti-CD3 mAb treatment induces IL-10 release.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a   SCI SCIE SCOPUS

    Lanzillo, Roberta (Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università) , Carbone, Fortunata (degli Studi di Napoli “Federico II”, Napoli, Italy ) , Quarantelli, Mario (Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy ) , Bruzzese, Dario (Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Napoli, Italy ) , Carotenuto, Antonio (Dipartimento di Sanità) , De Rosa, Veronica (Pubblica, Università) , Colamatteo, Alessandra (degli Studi di Napoli “Federico II”, Napoli, Italy ) , Micillo, Teresa (Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università) , De Luca Picione, Carla (degli Studi di Napoli “Federico II”, Napoli, Italy ) , Saccà (Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy ) , , Francesco (Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy ) , De Rosa, Anna (Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy ) , Moccia, Marcello (Dipartimento di Neuroscienz) , Brescia Morra, Vincenzo , Matarese, Giuseppe
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 249 - 253 , 2017 , 1521-6616 ,

    초록

    Abstract Reliable immunologic biomarkers able to monitor disease course during multiple sclerosis (MS) are still missing. We aimed at identifying possible immunometabolic biomarkers able to predict the clinical outcome in MS patients during treatment with interferon (IFN)-beta-1a. We measured in 45 relapsing-remitting (RR) MS patients, blood circulating levels of several immunometabolic markers, at enrolment, and correlated their levels to disease activity and progression over time. Higher levels of interleukin (IL)-6, soluble-CD40-ligand (sCD40L) and leptin at baseline associated with a higher relapse rate and a greater risk of experiencing at least one relapse in the following year. Higher values of soluble tumor necrosis factor receptor (sTNF-R) and leptin at baseline were predictive of a higher number of lesions in the following one-year of follow up. In conclusion, our data suggest that an immunometabolic profiling measuring IL-6, sCD40L, leptin and sTNF-R at baseline, could represent a useful tool to predict disease course in RRMS patients during treatment with IFN-beta-1a. Highlights Identification of possible biomarkers assessing therapeutic efficacy is a major goal in MS monitoring and prognosis. Baseline lower levels of MCP-1 positively correlate with MS activity. Baseline higher levels of IL-6 and leptin positively correlate with MS severity. sCD40-L, leptin and IL-6 act as predictors of number of relapses. sTNF-R levels are related with risk to develop acute lesions on MRI.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Nucleosomes and neutrophil extracellular traps in septic and burn patients   SCI SCIE SCOPUS

    Kaufman, Tomá (Laboratory of Experimental Thrombosis, Institute of Experimental Medicine-CONICET, National Academy of Medicine, José) , s (Andrés Pacheco de Melo 3081, Buenos Aires, Argentina ) , Magosevich, Dé (Sagrado Corazón Clinic, Bartolomé) , bora (Mitre 1955, Buenos Aires, Argentina ) , Moreno, Marí (Bazterrica Clinic, Billinghurst 2072, Buenos Aires, Argentina ) , a Carolina (Dr. Umberto Illia Burn Hospital, Av. Pedro Goyena 369, Buenos Aires, Argentina ) , Guzman, Marí (Laboratory of Experimental Thrombosis, Institute of Experimental Medicine-CONICET, National Academy of Medicine, José) , a Alejandra (Andrés Pacheco de Melo 3081, Buenos Aires, Argentina ) , D'Atri, Lina Paola (Laboratory of Experimental Thrombosis, Institute of Experimental Medicine-CONICET, National Academy of Medicine, José) , Carestia, Agostina (Andrés Pacheco de Melo 3081, Buenos Aires, Argentina ) , Fandiñ (Sagrado Corazón Clinic, Bartolomé) , o, Marí (Mitre 1955, Buenos Aires, Argentina ) , a Eugenia (Bazterrica Clinic, Billinghurst 2072, Buenos Aires, Argentina ) , Fondevila, Carlos (Laboratory of Experimental Thrombosis, Institute of Experi) , Schattner, Mirta
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 254 - 262 , 2017 , 1521-6616 ,

    초록

    Abstract NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1 and 4days post-admission (dpa). Nucleosomes were elevated in patients. In septics, they correlated with Human Neutrophil Elastase (HNE)-DNA complexes and SOFA score at 1dpa, and were associated with mortality. Patient's neutrophils had spontaneous NETosis and were unresponsive to stimulation. Although platelet P-selectin and TNF-α were increased in both groups, higher platelet TLR-4 expression, VWF levels and IL-6 were found in septics at 1dpa. Neither platelet activation markers nor cytokines correlated with nucleosomes or HNE-DNA. Nucleosomes could be indicators of organ damage and predictors of mortality in septic but not in burn patients. Platelet activation, VWF and cytokines do not appear to be key mediators of NETosis in these patient groups. Highlights Nucleosomes and HNE-DNA complexes are elevated in septic and burn patients. Septics' nucleosomes correlate with SOFA at 1dpa and were associated with mortality. Patient's neutrophils exhibit spontaneous NETosis and are unresponsive to stimulation. Nucleosomes could be organ damage indicators and mortality predictors in septics. Platelets, VWF and cytokines do not seem to mediate NETosis in these patients.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells   SCI SCIE SCOPUS

    Massaad, Michel J. (Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA ) , Cangemi, Brittney (Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA ) , Al-Herz, Waleed (Department of Pediatrics, Faculty of Medicine, Kuwait University, and Allergy and Clinical Immunology Unit, Department of Pediatrics, Al-Sabah Hospital, Kuwait ) , LeFranc, Gé (Institut de Génétique Humaine, UMR 9002 CNRS-Université) , rard (de Montpellier, Montpellier, France ) , Freeman, Alexandra (National Institutes of Health, Bethesda, MD 20892, USA ) , Baxi, Sachin (Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA ) , Keles, Sevgi (Division of Pediatric Allergy and Immunology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey ) , Metin, Ayse (Department of Pediatric Allergy and Immunology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey ) , Dasouki, Majid (Department of Pediatrics, and Department of Internal Medicine, Division of Genetics, Endocrinology & Metabolism, University of Kansas Medical Center, Kansas City, KS 66215, USA ) , Sobh, Ali (Departmen) , Kanariou, Maria , Al-Sukaiti, Nashat , Ozen, Ahmet , Ochs, Hans , Chatila, Talal A. , Manis, John P. , Geha, Raif
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 263 - 265 , 2017 , 1521-6616 ,

    초록

    Abstract NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1 and 4days post-admission (dpa). Nucleosomes were elevated in patients. In septics, they correlated with Human Neutrophil Elastase (HNE)-DNA complexes and SOFA score at 1dpa, and were associated with mortality. Patient's neutrophils had spontaneous NETosis and were unresponsive to stimulation. Although platelet P-selectin and TNF-α were increased in both groups, higher platelet TLR-4 expression, VWF levels and IL-6 were found in septics at 1dpa. Neither platelet activation markers nor cytokines correlated with nucleosomes or HNE-DNA. Nucleosomes could be indicators of organ damage and predictors of mortality in septic but not in burn patients. Platelet activation, VWF and cytokines do not appear to be key mediators of NETosis in these patient groups. Highlights Nucleosomes and HNE-DNA complexes are elevated in septic and burn patients. Septics' nucleosomes correlate with SOFA at 1dpa and were associated with mortality. Patient's neutrophils exhibit spontaneous NETosis and are unresponsive to stimulation. Nucleosomes could be organ damage indicators and mortality predictors in septics. Platelets, VWF and cytokines do not seem to mediate NETosis in these patients.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Increased expression of interleukin-21 along colorectal adenoma-carcinoma sequence and its predicating significance in patients with sporadic colorectal cancer   SCI SCIE SCOPUS

    Cui, Guanglin (Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China ) , Yuan, Aping (Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China ) , Zhu, Li (Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China ) , Florholmen, Jon (Research Group of Gastroenterology and Nutrition, Norwegian Arctic University, Tromsø, Norway ) , Goll, Rasmus (Research Group of Gastroenterology and Nutrition, Norwegian Arctic University, Tromsø, Norway)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 266 - 272 , 2017 , 1521-6616 ,

    초록

    Abstract The role and significance of interleukin (IL)-21 in the development of sporadic CRC have not been well defined. The aim of this study is therefore to investigate the dynamics of the IL-21 along colorectal adenoma-carcinoma sequence and to evaluate the impact of IL-21 on clinicopathological parameters and CRC prognosis. The real-time PCR results showed that the level of IL-21 in adenomas ( n = 50) and sporadic CRC ( n = 50) were significantly higher than that in normal controls ( n = 18), which were predominately observed in the adenoma/CRC stroma. Analysis revealed that IL-21 level was correlated with the overall survival time in CRC patients. Double immunofluorescence observations confirmed that IL-21 positive cells were mostly natural killer cells and T lymphocytes in the tumor stroma. These results indicate that significant increased IL-21 expression present within the adenoma/CRC microenvironment might have a potential predicating significance for survival time in patients with CRC. Highlights Significant increased expression of IL-21 is observed in the adenoma/CRC microenvironment IL-21 positive and IL-21 receptor positive cells were mostly immune cells including T lymphocytes, natural killer cells, and immature dendritic cells Increased IL-21 has a potential predicating significance for overall survival time in patients with sporadic CRC

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  9. [해외논문]   Severe Toxoplasma gondii infection in a member of a NFKB2-deficient family with T and B cell dysfunction   SCI SCIE SCOPUS

    Maccari, Maria-Elena (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Pediatric Immunohematology Unit, San Raffaele Scientific Institute, Milan, Italy ) , Scarselli, Alessia (University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy ) , Di Cesare, Silvia (University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy ) , Floris, Matteo (Crs4, Biomedicine, Pula, CA, Italy ) , Angius, Andrea (Crs4, Biomedicine, Pula, CA, Italy ) , Deodati, Annalisa (University Department of Pediatrics, Endocrinology Unit, Childrens' Hospital Bambino Gesù, Italy ) , Chiriaco, Maria (University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Italy ) , Cambiaso, Paola (University Department of Pediatrics, Endocrinology Unit, Childrens' Hospital Bambino Gesù, Italy ) , Corrente, Stefania (Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy ) , Colafati, Giovanna Stefania (Department of Imaging, Neuroradiology Unit, Childrens' Hospital Bambino Gesù, Italy ) , Utz, Paul J. (Department of Medicin) , Angelini, Federica , Fierabracci, Alessandra , Aiuti, Alessandro , Carsetti, Rita , Rosenberg, Jacob M. , Cappa, Marco , Rossi, Paolo , Bacchetta, Rosa , Cancrini, Caterina
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 273 - 277 , 2017 , 1521-6616 ,

    초록

    Abstract The role and significance of interleukin (IL)-21 in the development of sporadic CRC have not been well defined. The aim of this study is therefore to investigate the dynamics of the IL-21 along colorectal adenoma-carcinoma sequence and to evaluate the impact of IL-21 on clinicopathological parameters and CRC prognosis. The real-time PCR results showed that the level of IL-21 in adenomas ( n = 50) and sporadic CRC ( n = 50) were significantly higher than that in normal controls ( n = 18), which were predominately observed in the adenoma/CRC stroma. Analysis revealed that IL-21 level was correlated with the overall survival time in CRC patients. Double immunofluorescence observations confirmed that IL-21 positive cells were mostly natural killer cells and T lymphocytes in the tumor stroma. These results indicate that significant increased IL-21 expression present within the adenoma/CRC microenvironment might have a potential predicating significance for survival time in patients with CRC. Highlights Significant increased expression of IL-21 is observed in the adenoma/CRC microenvironment IL-21 positive and IL-21 receptor positive cells were mostly immune cells including T lymphocytes, natural killer cells, and immature dendritic cells Increased IL-21 has a potential predicating significance for overall survival time in patients with sporadic CRC

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  10. [해외논문]   Two novel mutations in ZAP70 gene that result in human immunodeficiency   SCI SCIE SCOPUS

    Llamas-Guillé (Morelos Children Hospital, Mexico ) , n, Beatriz Adriana (Cell Dynamics Research Center-IICBA, Autonomous University of Morelos State, Mexico ) , Pastor, Nina (National Institute of Pediatrics, Mexico ) , Ló (National Institute of Pediatrics, Mexico ) , pez-Herrera, Gabriela (School of Medicine, Autonomous University of Morelos State, Mexico ) , Gonzá (School of Medicine, Autonomous University of Morelos State, Mexico ) , lez-Serrano, Maria Edith (Cell Dynamics Research Center-IICBA, Autonomous University of Morelos State, Mexico ) , Valenzuela-Vá (Biotechnology Institute, Autonomous National University of México, Mexico ) , zquez, Lucero (Biotechnology Institute, Autonomous National University of México, Mexico ) , Bravo-Adame, Maria Elena (Cell Dynamics Research Center-IICBA, Autonomous University of Morelos State, Mexico ) , Villanueva-Cabello, Tania Maria (Morelos Children Hospital, Mexico ) , Gaytá (Clinical Research Institute of Montreal, Canada ) , n, Paul (National Institute of Pediatrics, Mexico ) , Yañ (School of Medicine, Autonomous University of Morelos State, Mexico) , ez, Jorge , Martinez-Duncker, Ivan , Ruiz-Ferná , ndez, Miguel , Veillette, André , , Espinosa-Padilla, Sara Elva , Cruz-Munoz, Mario Ernesto
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 278 - 284 , 2017 , 1521-6616 ,

    초록

    Highlights Two novel mutations in ZAP70 in a patient with an early-onset immunodeficiency are described. Both mutations resulted in partial absence of ZAP-70 protein and were ineffective to promote TCR-dependent signals. Our findings extend the genetic etiology and molecular characterization of ZAP-70 mutations that lead to early onset immunodeficiency.

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