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Nanomaterials 51건

  1. [해외논문]   Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles   SCIE

    Baek, Jong-Suep , Na, Young-Guk , Cho, Cheong-Weon
    Nanomaterials v.8 no.3 ,pp. 159 , 2018 ,

    초록

    While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of wogonin was observed in stearic acid. Hence, wogonin-loaded solid lipid nanoparticles were composed of stearic acid as the lipid matrix. The physicochemical properties of the wogonin-loaded solid lipid nanoparticles were evaluated by dynamic laser scattering and scanning electron microscopy. The wogonin-loaded solid lipid nanoparticles exhibited sustained and controlled release up to 72 h. In addition, it was observed that the wogonin-loaded solid lipid nanoparticles exhibited enhanced cytotoxicity and inhibited poly (ADP-ribose) polymerase in MCF-7 breast cancer cells. Overall, the results indicate that wogonin-loaded solid lipid nanoparticles could be an efficient delivery system for the treatment of breast cancer.

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  2. [해외논문]   In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO 2   SCIE

    Wiemann, Martin (IBR R&D gGmbH Institute for Lung Health, Mendelstr. 11, 48149 Münster, Germany) , Sauer, Ursula G. (vennemann@ibe-ms.de ) , Vennemann, Antje (Scientific Consultancy—Animal Welfare, 85579 Neubiberg, Germany) , Bä (ursula.sauer@sauerug.de ) , cker, Sandra (IBR R&D gGmbH Institute for Lung Health, Mendelstr. 11, 48149 Münster, Germany) , Keller, Johannes-Georg (vennemann@ibe-ms.de ) , Ma-Hock, Lan (BASF SE, Human Biomonitoring and Industrial Hygiene, 67056 Ludwigshafen, Germany) , Wohlleben, Wendel (sandra.baecker@basf.com ) , Landsiedel, Robert (BASF SE, Advanced Materials Research, 67056 Ludwigshafen, Germany)
    Nanomaterials v.8 no.3 ,pp. 160 , 2018 ,

    초록

    In vitro prediction of inflammatory lung effects of well-dispersed nanomaterials is challenging. Here, the in vitro effects of four colloidal amorphous SiO 2 nanomaterials that differed only by their primary particle size (9, 15, 30, and 55 nm) were analyzed using the rat NR8383 alveolar macrophage (AM) assay. Data were compared to effects of single doses of 15 nm and 55 nm SiO 2 intratracheally instilled in rat lungs. In vitro, all four elicited the release of concentration-dependent lactate dehydrogenase, β-glucuronidase, and tumor necrosis factor alpha, and the two smaller materials also released H 2 O 2 . All effects were size-dependent. Since the colloidal SiO 2 remained well-dispersed in serum-free in vitro conditions, effective particle concentrations reaching the cells were estimated using different models. Evaluating the effective concentration–based in vitro effects using the Decision-making framework for the grouping and testing of nanomaterials, all four nanomaterials were assigned as “active.” This assignment and the size dependency of effects were consistent with the outcomes of intratracheal instillation studies and available short-term rat inhalation data for 15 nm SiO 2 . The study confirms the applicability of the NR8383 AM assay to assessing colloidal SiO 2 but underlines the need to estimate and consider the effective concentration of such well-dispersed test materials.

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  3. [해외논문]   Understanding the Effects of NaCl, NaBr and Their Mixtures on Silver Nanowire Nucleation and Growth in Terms of the Distribution of Electron Traps in Silver Halide Crystals   SCIE

    Rui, Yunjun (Department of Applied Physics, Nanjing Tech University, Nanjing 210009, China) , Zhao, Weiliang (weiliangzhao100@126.com (W.Z.)) , Zhu, Dewei (wanghengyu@njtech.edu.cn (H.W.)) , Wang, Hengyu (dwgu@njtech.edu.cn (D.G.)) , Song, Guangliang (xbingtang@126.com (X.T)) , Swihart, Mark T. (yingyang@njtech.edu.cn (Y.Y.)) , Wan, Neng (tyzhang@njtech.edu.cn (T.Z.) ) , Gu, Dawei (Department of Applied Physics, Nanjing Tech University, Nanjing 210009, China) , Tang, Xiaobing (weiliangzhao100@126.com (W.Z.)) , Yang, Ying (wanghengyu@njtech.edu.cn (H.W.)) , Zhang, Tianyou (dwgu@njtech.edu.cn (D.G.))
    Nanomaterials v.8 no.3 ,pp. 161 , 2018 ,

    초록

    In recent years, many research groups have synthesized ultra-thin silver nanowires (AgNWs) with diameters below 30 nm by employing Cl − and Br − simultaneously in the polyol process. However, the yield of AgNWs in this method was low, due to the production of Ag nanoparticles (AgNPs) as an unwanted byproduct, especially in the case of high Br − concentration. Here, we investigated the roles of Cl − and Br − in the preparation of AgNWs and then synthesized high aspect ratio (up to 2100) AgNWs in high yield (>85% AgNWs) using a Cl − and Br − co-mediated method. We found that multiply-twinned particles (MTPs) with different critical sizes were formed and grew into AgNWs, accompanied by a small and large amount of AgNPs for the NaCl and NaBr additives, respectively. For the first time, we propose that the growth of AgNWs of different diameters and yields can be understood based on the electron trap distribution (ETD) of the silver halide crystals. For the case of Cl − and Br − co-additives, a mixed silver halide crystal of AgBr 1− x Cl x was formed, rather than the AgBr/AgCl mixture reported previously. In this type of crystal, the ETD is uniform, which is beneficial for the synthesis of AgNWs with small diameter (30~40 nm) and high aspect ratio. AgNW transparent electrodes were prepared in air by rod coating. A sheet resistance of 48 Ω/sq and transmittance of 95% at 550 nm were obtained without any post-treatment.

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  4. [해외논문]   One-Step Fabrication of Dual Responsive Lignin Coated Fe 3 O 4 Nanoparticles for Efficient Removal of Cationic and Anionic Dyes   SCIE

    Li, Xingang (School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China) , He, Youyi (lxg@tju.edu.cn (X.L.)) , Sui, Hong (youyihe@tju.edu.cn (Y.H.)) , He, Lin (suihong@tju.edu.cn (H.S.) )
    Nanomaterials v.8 no.3 ,pp. 162 , 2018 ,

    초록

    A new, simple one-step approach has been developed to synthesize lignin and lignin amine coated Fe 3 O 4 nanoparticles. These nanoparticles (lignin magnetic nanoparticles (LMNPs) and lignin amine magnetic nanoparticles (LAMNPs)) are found to possess not only magnetic response but also pH-dependent adsorption behavior. Results show that the combination of lignin with nanoparticles increased the adsorption capacities 2–5 times higher than other traditional single lignin based adsorbents (211.42 mg/g for methylene blue (MB) by LMNPs and 176.49 mg/g for acid scarlet GR (AS-GR) by LAMNPs). Meanwhile, by simply adjusting the pH, the dye-loaded adsorbents can be regenerated to recycle both adsorbents and dyes with a desorption efficiency up to 90%. Mechanistic study shows that dye structure and surface charges of adsorbents play the most important part in adsorption where dyes interact with the adsorbent surface via π–π stacking and electrostatic attraction interactions. The efficient fabrication method, eco-friendly reactant, quick magnetic separation, high adsorption and desorption efficiency suggest this novel type of nano-adsorbents to be promising materials for efficient dye pollutant removal and recovery.

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  5. [해외논문]   The Preparation of Graphene Oxide-Silver Nanocomposites: The Effect of Silver Loads on Gram-Positive and Gram-Negative Antibacterial Activities   SCIE

    Vi, Truong Thi Tuong (Department of Chemical and Materials Engineering and Green Technology Research Center, Chang Gung University, Taoyuan City 333, Taiwan) , Rajesh Kumar, Selvaraj (truongthituongvi005@gmail.com (T.T.T.V.)) , Rout, Bishakh (rajeshkumarnst@gmail.com (S.R.K.) ) , Liu, Chi-Hsien (Department of Chemical and Materials Engineering and Green Technology Research Center, Chang Gung University, Taoyuan City 333, Taiwan) , Wong, Chak-Bor (truongthituongvi005@gmail.com (T.T.T.V.)) , Chang, Chia-Wei (rajeshkumarnst@gmail.com (S.R.K.) ) , Chen, Chien-Hao (Department of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan City 333, Taiwan) , Chen, Dave W. (bishakh4fun@gmail.com (B.R.)) , Lue, Shingjiang Jessie (chl@mail.cgu.edu.tw (C.-H.L.) )
    Nanomaterials v.8 no.3 ,pp. 163 , 2018 ,

    초록

    In this work, silver nanoparticles (Ag NPs) were decorated on thiol (–SH) grafted graphene oxide (GO) layers to investigate the antibacterial activities in Gram-positive bacteria ( Staphylococcus aureus ) and Gram-negative bacteria ( Pseudomonas aeruginosa ). The quasi-spherical, nano-sized Ag NPs were attached to the GO surface layers, as confirmed by using field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM), respectively. The average size of GO-Ag nanocomposites was significantly reduced (327 nm) from those of pristine GO (962 nm) while the average size of loaded Ag NPs was significantly smaller than the Ag NPs without GO. Various concentrations of AgNO 3 solutions (0.1, 0.2, and 0.25 M) were loaded into GO nanosheets and resulted in the Ag contents of 31, 43, and 65%, respectively, with 1–2 nm sizes of Ag NPs anchored on the GO layers. These GO-Ag samples have negative surface charges but the GO-Ag 0.2 M sample (43% Ag) demonstrated the highest antibacterial efficiency. At 10 ppm load of GO-Ag suspension, only a GO-Ag 0.2 M sample yielded slight bacterial inhibition (5.79–7.82%). As the GO-Ag content was doubled to 20 ppm, the GO-Ag 0.2 M composite exhibited ~49% inhibition. When the GO-Ag 0.2 M composite level was raised to 100 ppm, almost 100% inhibition efficiencies were found on both Staphylococcus aureus (S.A.) and Pseudomonas aeruginosa (P.A.), which were significantly higher than using pristine GO (27% and 33% for S.A. and P.A.). The combined effect of GO and Ag nanoparticles demonstrate efficient antibacterial activities.

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  6. [해외논문]   Enhancing the Microparticle Deposition Stability and Homogeneity on Planer for Synthesis of Self-Assembly Monolayer   SCIE

    Shih, An-Ci , Han, Chi-Jui , Kuo, Tsung-Cheng , Cheng, Yun-Chien
    Nanomaterials v.8 no.3 ,pp. 164 , 2018 ,

    초록

    The deposition stability and homogeneity of microparticles improved with mask, lengthened nozzle and flow rate adjustment. The microparticles can be used to encapsulate monomers, before the monomers in the microparticles can be deposited onto a substrate for nanoscale self-assembly. For the uniformity of the synthesized nanofilm, the homogeneity of the deposited microparticles becomes an important issue. Based on the ANSYS simulation results, the effects of secondary flow were minimized with a lengthened nozzle. The ANSYS simulation was also used to investigate the ring-vortex generation and why the ring vortex can be eliminated by adding a mask with an aperture between the nozzle and deposition substrate. The experimental results also showed that particle deposition with a lengthened nozzle was more stable, while adding the mask stabilized deposition and diminished the ring-vortex contamination. The effects of flow rate and pressure were also investigated. Hence, the deposition stability and homogeneity of microparticles was improved.

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  7. [해외논문]   The Effect of Laminin Surface Modification of Electrospun Silica Nanofiber Substrate on Neuronal Tissue Engineering   SCIE

    Chen, Wen Shuo (Center for Nanotechnology, Center for Biomedical Technology, Department of Chemistry, Chung Yuan Christian University, Taoyuan 32023, Taiwan) , Guo, Ling Yu (allanson92@yahoo.com.tw (W.S.C.)) , Tang, Chia Chun (sunny_day80917@yahoo.com.tw (L.Y.G.)) , Tsai, Cheng Kang (wesley741129@gmail.com (C.C.T.)) , Huang, Hui Hua (chengkang20071994@gmail.com (C.K.T.)) , Chin, Ting Yu (jenny16155@gmail.com (H.H.H.) ) , Yang, Mong-Lin (Center for Nanotechnology, Center for Biomedical Technology, Department of Chemistry, Chung Yuan Christian University, Taoyuan 32023, Taiwan) , Chen-Yang, Yui Whei (allanson92@yahoo.com.tw (W.S.C.))
    Nanomaterials v.8 no.3 ,pp. 165 , 2018 ,

    초록

    In this study, we first synthesized a slow-degrading silica nanofiber (SNF2) through an electrospun solution with an optimized tetraethyl orthosilicate (TEOS) to polyvinyl pyrrolidone (PVP) ratio. Then, laminin-modified SNF2, namely SNF2-AP-S-L, was obtained through a series of chemical reactions to attach the extracellular matrix protein, laminin, to its surface. The SNF2-AP-S-L substrate was characterized by a combination of scanning electron microscopy (SEM), Fourier transform–infrared (FTIR) spectroscopy, nitrogen adsorption/desorption isotherms, and contact angle measurements. The results of further functional assays show that this substrate is a biocompatible, bioactive and biodegradable scaffold with good structural integrity that persisted beyond 18 days. Moreover, a synergistic effect of sustained structure support and prolonged biochemical stimulation for cell differentiation on SNF2-AP-S-L was found when neuron-like PC12 cells were seeded onto its surface. Specifically, neurite extensions on the covalently modified SNF2-AP-S-L were significantly longer than those observed on unmodified SNF and SNF subjected to physical adsorption of laminin. Together, these results indicate that the SNF2-AP-S-L substrate prepared in this study is a promising 3D biocompatible substrate capable of sustaining longer neuronal growth for tissue-engineering applications.

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  8. [해외논문]   The Hydrolytic Stability and Degradation Mechanism of a Hierarchically Porous Metal Alkylphosphonate Framework   SCIE

    Lv, Kai , Yang, Chu-Ting , Liu, Yi , Hu, Sheng , Wang, Xiao-Lin
    Nanomaterials v.8 no.3 ,pp. 166 , 2018 ,

    초록

    To aid the design of a hierarchically porous unconventional metal-phosphonate framework (HP-UMPF) for practical radioanalytical separation, a systematic investigation of the hydrolytic stability of bulk phase against acidic corrosion has been carried out for an archetypical HP-UMPF. Bulk dissolution results suggest that aqueous acidity has a more paramount effect on incongruent leaching than the temperature, and the kinetic stability reaches equilibrium by way of an accumulation of a partial leached species on the corrosion conduits. A variation of particle morphology, hierarchical porosity and backbone composition upon corrosion reveals that they are hydrolytically resilient without suffering any great degradation of porous texture, although large aggregates crack into sporadic fractures while the nucleophilic attack of inorganic layers cause the leaching of tin and phosphorus. The remaining selectivity of these HP-UMPFs is dictated by a balance between the elimination of free phosphonate and the exposure of confined phosphonates, thus allowing a real-time tailor of radionuclide sequestration. Moreover, a plausible degradation mechanism has been proposed for the triple progressive dissolution of three-level hierarchical porous structures to elucidate resultant reactivity. These HP-UMPFs are compared with benchmark metal-organic frameworks (MOFs) to obtain a rough grading of hydrolytic stability and two feasible approaches are suggested for enhancing their hydrolytic stability that are intended for real-life separation protocols.

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  9. [해외논문]   A Modular Coassembly Approach to All-In-One Multifunctional Nanoplatform for Synergistic Codelivery of Doxorubicin and Curcumin   SCIE

    Yang, Muyang (Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China) , Yu, Lixia (yangmuyang@tju.edu.cn (M.Y.)) , Guo, Ruiwei (lixiayu@tju.edu.cn (L.Y.)) , Dong, Anjie (rwguo@tju.edu.cn (R.G.)) , Lin, Cunguo (ajdong@tju.edu.cn (A.D.) ) , Zhang, Jianhua (Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China)
    Nanomaterials v.8 no.3 ,pp. 167 , 2018 ,

    초록

    Synergistic combination therapy by integrating chemotherapeutics and chemosensitizers into nanoparticles has demonstrated great potential to reduce side effects, overcome multidrug resistance (MDR), and thus improve therapeutic efficacy. However, with regard to the nanocarriers for multidrug codelivery, it remains a strong challenge to maintain design simplicity, while incorporating the desirable multifunctionalities, such as coloaded high payloads, targeted delivery, hemodynamic stability, and also to ensure low drug leakage before reaching the tumor site, but simultaneously the corelease of drugs in the same cancer cell. Herein, we developed a facile modular coassembly approach to construct an all-in-one multifunctional multidrug delivery system for the synergistic codelivery of doxorubicin (DOX, chemotherapeutic agent) and curcumin (CUR, MDR modulator). The acid-cleavable PEGylated polymeric prodrug (DOX- h -PCEC), tumor cell-specific targeting peptide (CRGDK-PEG-PCL), and natural chemosensitizer (CUR) were ratiometrically assembled into in one single nanocarrier (CUR/DOX- h -PCEC@CRGDK NPs). The resulting CUR/DOX- h -PCEC@CRGDK NPs exhibited several desirable characteristics, such as efficient and ratiometric drug loading, high hemodynamic stability and low drug leakage, tumor intracellular acid-triggered cleavage, and subsequent intracellular simultaneous drug corelease, which are expected to maximize a synergistic effect of chemotherapy and chemosensitization. Collectively, the multifunctional nanocarrier is feasible for the creation of a robust nanoplatform for targeted multidrug codelivery and efficient MDR modulation.

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  10. [해외논문]   Supramolecular Control over the Interparticle Distance in Gold Nanoparticle Arrays by Cyclodextrin Polyrotaxanes   SCIE

    Paulo Coelho, Joao , Osí , o Barcina, José , , Junquera, Elena , Aicart, Emilio , Tardajos, Gloria , Gó , mez-Grañ , a, Sergio , Cruz-Gil, Pablo , Salgado, Cá , stor , Dí , az-Nú , ñ , ez, Pablo , Peñ , a-Rodrí , guez, Ovidio , Guerrero-Martí , nez, André , s
    Nanomaterials v.8 no.3 ,pp. 168 , 2018 ,

    초록

    Synergistic combination therapy by integrating chemotherapeutics and chemosensitizers into nanoparticles has demonstrated great potential to reduce side effects, overcome multidrug resistance (MDR), and thus improve therapeutic efficacy. However, with regard to the nanocarriers for multidrug codelivery, it remains a strong challenge to maintain design simplicity, while incorporating the desirable multifunctionalities, such as coloaded high payloads, targeted delivery, hemodynamic stability, and also to ensure low drug leakage before reaching the tumor site, but simultaneously the corelease of drugs in the same cancer cell. Herein, we developed a facile modular coassembly approach to construct an all-in-one multifunctional multidrug delivery system for the synergistic codelivery of doxorubicin (DOX, chemotherapeutic agent) and curcumin (CUR, MDR modulator). The acid-cleavable PEGylated polymeric prodrug (DOX- h -PCEC), tumor cell-specific targeting peptide (CRGDK-PEG-PCL), and natural chemosensitizer (CUR) were ratiometrically assembled into in one single nanocarrier (CUR/DOX- h -PCEC@CRGDK NPs). The resulting CUR/DOX- h -PCEC@CRGDK NPs exhibited several desirable characteristics, such as efficient and ratiometric drug loading, high hemodynamic stability and low drug leakage, tumor intracellular acid-triggered cleavage, and subsequent intracellular simultaneous drug corelease, which are expected to maximize a synergistic effect of chemotherapy and chemosensitization. Collectively, the multifunctional nanocarrier is feasible for the creation of a robust nanoplatform for targeted multidrug codelivery and efficient MDR modulation.

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