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Clinical immunology : the official journal of the ... 49건

  1. [해외논문]   Asthmatic farm children show increased CD3+ CD8low T-cells compared to non-asthmatic farm children   SCI SCIE SCOPUS

    Twardziok, Monika (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) , Schrö (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) , der, Paul C. (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) , Krusche, Johanna (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) , Casaca, Vera I. (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) , Illi, Sabina (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) , Bö (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) , ck, Andreas (Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany ) , Loss, Georg J. (Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany ) , Kabesch, Michael (Zurich University Children's Hospital, Zurich, Switzerland ) , Toncheva, Antoaneta A. (Dr. von Hauner Children's Hospital, Ludwig Maximilians) , Roduit, Caroline , Depner, Martin , Genuneit, Jon , Renz, Harald , Roponen, Marjut , Weber, Juliane , Braun-Fahrlä , nder, Charlotte , Riedler, Josef , Lauener, Roger , Vuitton, Dominique Angè , le , Dalphin, Jean-Charles , Pekkanen, Juha , von Mutius, Erika , Schaub, Bianca , Hyvä , rinen, Anne , Karvonen, Anne M. , Kirjavainen, Pirkka V. , Remes, Sami , Kaulek, Vincent , Dalphin, Marie-Laure , Ege, Markus , Pfefferle, Petra I. , Doekes, Gert
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 285 - 292 , 2017 , 1521-6616 ,

    초록

    Highlights Asthmatic farm children exhibit more CD3 + CD8 low T-cells compared to non-asthmatic farm children. IFN-γ secretion is decreased in asthmatic compared to non-asthmatic farm-exposed children Asthmatic farm children with asthma risk alleles have more CD3 + CD8 low T-cells than non-asthmatic children with risk alleles. The amount of CD8 low T-cells indicates a specific farm-dependent mechanism associated with childhood asthma.

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  2. [해외논문]   Increased innate type 2 immune response in house dust mite-allergic patients with allergic rhinitis   SCI SCIE SCOPUS

    Zhong, Hua (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Fan, Xing-Liang (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Yu, Qiu-Ning (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Qin, Zi-Li (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Chen, Dong (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Xu, Rui (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Chen, De-Hua (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Lin, Zhi-Bin (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Wen, Weiping (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) , Fu, Qing-Ling (O)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 293 - 299 , 2017 , 1521-6616 ,

    초록

    Abstract Group 2 innate lymphoid cells (ILC2s) are essential in initiating and driving allergic immune responses. However, there were inconsistent findings of the ILC2 levels in allergic rhinitis (AR) patients. This study investigated the ILC2 levels in the peripheral blood of house dust mite (HDM)-sensitized AR patients and their ability to secrete type 2 cytokines. The levels of ILC2s with phenotypic ILC2 characteristics were increased in the HDM-AR patients. The AR patients' symptom score and IL-13 levels were positively associated with the ILC2s in HDM-AR patients. The epithelial cytokine stimulation induced dramatic production of IL-5 and IL-13 in PBMCs of AR patients. We successfully sorted ILC2s from AR patients and identified their ability of type 2 cytokines production. The number of ILC2s increased in the HDM-AR patients and ILC2s produced the amount of T H 2 cytokines in the presence of epithelial cytokines, which suggested the important role of ILC2 in AR patients. Highlights ILC2s was elevated in HDM-sensitized AR patients. ILC2s from AR patients produced more T H 2 cytokines. ILC2s may be involved in the HDM-AR, which could be a potential therapeutic target for AR.

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  3. [해외논문]   Antibodies against citrullinated alpha enolase peptides in primary Sjogren's syndrome   SCI SCIE SCOPUS

    Nezos, Adrianos (Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece ) , Cinoku, Ilir (Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece ) , Mavragani, Clio P. (Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece ) , Moutsopoulos, Haralampos M. (Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 300 - 303 , 2017 , 1521-6616 ,

    초록

    Abstract Citrullinated alpha enolase (CEP-1) has been designated as a major antigenic target of antibodies against citrullinated proteins (ACPA) in patients with rheumatoid arthritis (RA). Our aim is to determine the prevalence of anti-CEP-1 in a cohort of ACPA positive (ACPA+) primary Sjogren's syndrome (pSS) patients. Anti-CEP1 titers were determined by ELISA in sera from 15 ACPA+ and 45 ACPA- age/sex matched pSS; 12 ACPA+ RA patients and 30 healthy controls (HC). Increased anti-CEP-1 antibody titers were detected in nine out of the 15 (60%) ACPA+ pSS patients and 5 out of 12 (41.7%) ACPA+ RA patients; no reactivities were detected in ACPA- pSS patients and HC. Anti-CEP-1 antibodies in the setting of pSS were associated with higher urine pH levels at baseline. CEP-1 is a major antigenic target of ACPA in patients with pSS characterizing a subgroup with distinct laboratory features. Highlights CEP-1 is a major antigenic target of ACPA in patients with pSS. Anti-CEP-1 antibodies are associated with increased rates of non-erosive arthritis. Anti-CEP-1 antibodies are associated with higher urine pH at baseline.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Depressed serum IgM levels in SLE are restricted to defined subgroups   SCI SCIE SCOPUS

    Grö (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) , nwall, Caroline (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) , Hardt, Uta (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) , Gustafsson, Johanna T. (Department of Clinical Immunology and Transfusion Medicine, Unit of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) , Elvin, Kerstin (Department of Clinical Physiology, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden ) , Jensen-Urstad, Kerstin (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) , Kvarnströ (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) , m, Marika (Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden ) , Grosso, Giorgia (Department of Medicine, Rheumatology Unit, Karolinska Insti) , Rö , nnelid, Johan , Padykov, Leonid , Gunnarsson, Iva , Silverman, Gregg J. , Svenungsson, Elisabet
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 304 - 315 , 2017 , 1521-6616 ,

    초록

    Abstract Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls. Strikingly, an autoreactivity profile defined by IgG anti-Ro/La was associated with reduced levels of specific natural IgM targeting phosphorylcholine (PC) antigens and malondialdehyde (MDA) modified-protein, as well as total IgM, while no differences were detected in SLE patients with an autoreactivity profile defined by anti-cardiolipin/β 2 glycoprotein-I. We also observed an association of reduced IgM levels with the HLA-DRB1*03 allelic variant among SLE patients and controls. Associations of low IgM anti-PC with cardiovascular disease were primarily found in patients without antiphospholipid antibodies. These studies further highlight the clinical relevance of depressed IgM. Our results suggest that low IgM levels in SLE patients reflect immunological and genetic differences between SLE subgroups. Highlights Low IgM levels are more common in SLE patients than in controls. Patients with anti-Ro/La autoimmunity often have strikingly decreased IgM levels. Low IgM was seen for specific IgM anti-PC, anti-MDA, anti-CWPS, as well as total IgM. Low natural IgM may be associated to HLA-DRB1*03 in both SLE and controls.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Natural and induced immunization against CCL20 ameliorate experimental autoimmune encephalitis and may confer protection against multiple sclerosis   SCI SCIE SCOPUS

    Abraham, Michal (Biokine Therapeutics Ltd, Ness Ziona, Israel ) , Karni, Arnon (Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel ) , Mausner-Fainberg, Karin (Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel ) , Weiss, Ido D. (Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel ) , Peled, Amnon (Goldyne Savad Institute of Gene Therapy, Hebrew University Hospital, Jerusalem, Israel)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 316 - 324 , 2017 , 1521-6616 ,

    초록

    Abstract Th-17 type immune response that occurs in multiple sclerosis (MS) is linked to CCR6-CCL20 interaction. We confirmed the dependency on CCR6 in EAE development. Vaccination of mice with hCCL20, but not mCCL20, produced anti-murine CCL20 and ameliorated EAE. The EAE clinical score negatively correlated with anti CCL20 levels. A beneficial effect was transferred by sera from hCCL20-immunized mice. Immunized mice with cyclic peptide that include a bacterial outer membrane protein A (ompA), that share homology sequence with hCCL20 produced anti CCL20, anti ompA and anti-cyclic peptide. Immunization of mice with ompA or the cyclic peptide ameliorated EAE. The cyclic peptide inhibited CCL20 activity in an adhesion assay. A significantly higher level of anti CCL20 were found in healthy individuals compared to RR-MS patients. There was no similar difference for anti-CXCL10. Natural or induced immunization against CCL20 confer protection against EAE and may be beneficial in MS. Highlights Immunization of mice with hCCL20 produced autoantibodies against murine CCL20 and protected mice from MOG35-55-induced EAE. The EAE clinical score negatively correlated with the levels of antibodies against CCL20. A protective effect was adoptively transferred by sera from hCCL20-immunized mice into non-immunized mice with EAE. Immunization with peptide that share homology sequence of CCL20 and bacterial outer membrane protein A protect against EAE Higher levels of autoantibodies against CCL20 in the sera of healthy than in MS patients

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study   SCI SCIE SCOPUS

    Duffy, Darragh (Center for Translational Research, Institut Pasteur, Paris, France ) , Rouilly, Vincent (Center for Translational Research, Institut Pasteur, Paris, France ) , Braudeau, Cecile (CHU Nantes, Laboratoire d'Immunologie, CIMNA, Nantes, France ) , Corbiè (Laboratory of Vaccinology and Mucosal Immunity, Université) , re, Vé (Libre de Bruxelles (ULB), Brussels, Belgium ) , ronique (Center for Translational Research, Institut Pasteur, Paris, France ) , Djebali, Raouf (Center for Translational Research, Institut Pasteur, Paris, France ) , Ungeheuer, Marie-Noelle (CHU Nantes, Laboratoire d'Immunologie, CIMNA, Nantes, France ) , Josien, Regis (Myriad RBM Inc, Austin, TX, USA ) , LaBrie, Samuel T. (Laboratoire d'Immunologie clinique, CIC-4218 et Unité) , Lantz, Olivier (Inserm 932 Institut Curie, Paris, France ) , Louis, Delphine (Laboratoire d'Immunologie clinique, CIC-4218 et Unité) , Martinez-Caceres, Eva (Inserm 932 Institut Curie, Paris, France ) , Mascart, Francoise (Germans Trias i Pujol Hospital, Dept Cellular Biology, Physiology, Immunology, UAB, Barcelona, Spain ) , Ruiz de Morales, Jose G. (Laboratory of Vaccinology and Mucosal Immunity, Université) , Ottone, Catherine (Libre de Bruxelles (ULB), Brussels, Belgium ) , Redjah, Lydia (Complejo Asistencial Universi) , Guen, Nina Salabert-Le , Savenay, Alain , Schmolz, Manfred , Toubert, Antoine , Albert, Matthew L.
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 325 - 335 , 2017 , 1521-6616 ,

    초록

    Abstract Functional immune responses are increasingly important for clinical studies, providing in depth biomarker information to assess immunotherapy or vaccination. Incorporating functional immune assays into routine clinical practice has remained limited due to challenges in standardizing sample preparation. We recently described the use of a whole blood syringe-based system, TruCulture?, which permits point-of-care standardized immune stimulation. Here, we report on a multi-center clinical study in seven FOCIS Centers of Excellence to directly compare TruCulture to conventional PBMC methods. Whole blood and PBMCs from healthy donors were exposed to LPS, anti-CD3 anti-CD28 antibodies, or media alone. 55 protein analytes were analyzed centrally by Luminex multi-analyte profiling in a CLIA-certified laboratory. TruCulture responses showed greater reproducibility and improved the statistical power for monitoring differential immune response activation. The use of TruCulture addresses a major unmet need through a robust and flexible method for immunomonitoring that can be reproducibly applied in multi-center clinical studies. One sentence summary A multi-center study revealed greater reproducibility from whole blood stimulation systems as compared to PBMC stimulation for studying induced immune responses. Highlights FOCIS Centers of Excellence clinical study compared standardized whole blood TruCulture and PBMC stimulations TruCulture showed greater reproducibility across centers and improved statistical power for studying immune responses Significantly lower levels of non-specific cytokines were observed in whole blood stimulation as compared to PBMC cultures Significantly higher IL-23 and CXCL5 for LPS, and lower VEGF for CD3/CD28 stimulation in TruCulture as compared to PBMC

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes   SCI SCIE SCOPUS

    Hanley, Patrick (Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA ) , Sutter, Jennifer A. (Division of Endocrinology and Diabetes, East Carolina University Pediatrics Specialty Clinic, Greenville, NC, USA ) , Goodman, Noah G. (Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA ) , Du, Yangzhu (Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA ) , Sekiguchi, Debora R. (Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada ) , Meng, Wenzhao (Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA ) , Rickels, Michael R. (Division of Endocrinology, Diabetes and Metabolism, Hospital of the University of Pennsylvania, Philadelphia, PA, USA ) , Naji, Ali (Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA ) , Luning Prak, Eline T. (Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphi)
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 336 - 343 , 2017 , 1521-6616 ,

    초록

    Abstract Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that could improve individualized therapy. To evaluate B cell developmental progression in T1D, immunophenotyping was used to classify circulating B cells into transitional, mature naIve, mature activated, and resting memory subsets. Then each subset was analyzed for the expression of additional maturation-associated markers. While the frequencies of B cell subsets did not differ significantly between patients and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR). Furthermore, some T1D subjects had B cell subsets with lower frequencies of class switching. These results suggest circulating B cells exhibit variable maturation phenotypes in T1D. These phenotypic variations may correlate with differences in B cell selection in individual T1D patients.

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  8. [해외논문]   Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease   SCI SCIE SCOPUS

    Shindi, Reham (School of Life Sciences, The University of Nottingham, Nottingham, UK ) , Almehairi, Amna (School of Life Sciences, The University of Nottingham, Nottingham, UK ) , Negm, Ola H. (School of Life Sciences, The University of Nottingham, Nottingham, UK ) , Kalsheker, Noor (School of Life Sciences, The University of Nottingham, Nottingham, UK ) , Gale, Nichola S. (Physiotherapy Department, School of Healthcare Sciences, University Hospital of Wales, Cardiff University, Cardiff, UK ) , Shale, Dennis J. (Cardio-respiratory Medicine Department, Cardio-Respiratory Medicine, Wales Heart Research Institute, Cardiff University, University Hospital of Wales, Cardiff, UK ) , Harrison, Timothy W. (Division of Respiratory Medicine, School of Medicine, University of Nottingham, City Hospital Campus, Nottingham, UK ) , Bolton, Charlotte E. (Division of Respiratory Medicine, School of Medicine, University of Nottingham, City Hospital Campus, Nottingham, UK ) , John, Michelle (Division of Respiratory Medicine, School of Medicine, University of Nottingham, City Hospital Campus, Nottingham, UK ) , Todd, Ian (School of Life Sciences, The University of Nottingham, Nottingham, UK) , Tighe, Patrick J. , Fairclough, Lucy C.
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 344 - 353 , 2017 , 1521-6616 ,

    초록

    Abstract Autoimmunity occurs in chronic obstructive pulmonary disease (COPD). We describe an antigen microarray for detecting serum autoantibodies (AAbs) to determine how IgM, as well as IgG, AAbs distinguish patients with COPD from controls with a history of smoking without COPD. All COPD patients' sera contained elevated levels of AAbs to some of 30 autoantigens. There were significant differences in the autoantigenic specificities of IgM AAbs compared to IgG AAbs in the COPD sera: for example, AAbs to histone and scl-70 were mainly IgG, whereas AAbs to CENP-B and La/ssB were mainly IgM; by contrast, IgM and IgG AAbs to collagen-V were equally prevalent. Thus, a combination of IgM and IgG AAbs specific for multiple autoantigens are detected in all cases of COPD at a level at which all non-COPD controls are negative for AAbs. This highlights the importance of different classes of AAbs to a range of autoantigens in COPD. Highlights Autoimmunity occurs in chronic obstructive pulmonary disease (COPD), with production of autoantibodies (Aabs). Antigen microarray was used to detect IgM, as well as IgG, Aabs to 30 systemic autoantigens in COPD patients’ sera. All COPD patients’ sera contained elevated levels of Aabs to some autoantigens. Striking differences were seen in the autoantigenic specificities of IgM Aabs compared to IgG Aabs in COPD. A combination of IgM and IgG Aabs specific for multiple autoantigens were detected in all cases of COPD.

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  9. [해외논문]   Vaccination with a recombinant OprL fragment induces a Th17 response and confers serotype-independent protection against Pseudomonas aeruginosa infection in mice   SCI SCIE SCOPUS

    Gao, Chen (National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, PR China ) , Yang, Feng (National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, PR China ) , Wang, Ying (National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, PR China ) , Liao, Yaling (National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, PR China ) , Zhang, Jinyong (National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, P) , Zeng, Hao , Zou, Quanming , Gu, Jiang
    Clinical immunology : the official journal of the Clinical Immunology Society v.183 ,pp. 354 - 363 , 2017 , 1521-6616 ,

    초록

    Abstract Pseudomonas aeruginosa (PA) is the major causative agent of nosocomial infection. Despite of adequate use of antibiotics, it still represents a major challenge in controlling PA infection. The local pulmonary Th17 response plays an important protective role against PA infection. And the Th17-mediated protection is antibody independent, so we hypothesized that it would be an optimal strategy of a vaccine for PA control to induce an effective Th17 response. Herein we report the successful production of a recombinant fragment of the OprL (reOprL) of PA. Purified reOprL forms homogeneous monomers in solution and vaccination with reOprL elicited a remarkable Th17 response. In addition, reOprL vaccination conferred effective serotype-independent protection against PA infection, which relied on the Th17 response. Our data suggest that reOprL is a good candidate for the future development of Th17 immunity based PA vaccines. Highlights A recombinant fragment of the outer membrane protein OprL (reOprL) of PA was successful produced in soluble form. ReOprL forms homogeneous monomers in solution. Vaccination of reOprL elicited a remarkable Th17 response and confers serotype-independent protection. Th17 played an indispensable role in reOprL-induced protection.

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