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Evidence-based Complementary and Alternative Medic... 734건

  1. [해외논문]   Camellia sinensis(L.) Kuntze Extract Ameliorates Chronic Ethanol-Induced Hepatotoxicity in Albino Rats  

    Lodhi, Poonam (Environmental Endocrinology and Biomedical Research Unit, Department of Zoology, Meerut College, Meerut 250003, India ) , Tandan, Neeraj (Scientific and Applied Research Center, Meerut 250001, India ) , Singh, Neera (Environmental Endocrinology and Biomedical Research Unit, Department of Zoology, Meerut College, Meerut 250003, India ) , Kumar, Divyansh (D.A.V. (P.G.) College, Bulandshahr 203001, India ) , Kumar, Monu (Scientific and Applied Research Center, Meerut 250001, India)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 7 , 2014 , 1741-427x ,

    초록

    The goal of this study was to investigate the hepatoprotective effects of aqueous extract of Camellia sinensis or green tea extract (AQGTE) in chronic ethanol-induced albino rats. All animals were divided into 4 groups in the study for a 5-week duration. 50% ethanol was given orally to the rats with two doses (5 mg/kg bw and 10 mg/kg bw) of AQGTE. Ethanol administration caused a significant increase in the levels of plasma and serum enzymatic markers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), and nonenzymatic markers (cholesterol and triglycerides), lipid peroxidation contents, malondialdehyde (MDA), and glutathione-S-transferase (GST), and decreased the activities of total proteins, albumin, and cellular antioxidant defense enzymes such as superoxide dismutase (SOD). The elevation and reduction in these biochemical enzymes caused the damage in hepatocytes histologically due to the high production of ROS, which retards the antioxidant defense capacity of cell. AQGTE was capable of recovering the level of these markers and the damaged hepatocytes to their normal structures. These results support the suggestion that AQGTE was able to enhance hepatoprotective and antioxidant effects in vivo against ethanol-induced toxicity.

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  2. [해외논문]   Synergistic Effect of Fermented Rice Extracts on the Probiotic and Laxative Properties of Yoghurt in Rats with Loperamide-Induced Constipation  

    Choi, Jae-Suk (RIS Center, IACF, Silla University, Gwaebup-dong, Sasang-gu, Busan 617-736, Republic of Korea ) , Kim, Joo Wan (Glucan Corp. No. 305 Marine Bio-Industry Development Center, Hoenggye-ri 27, Ilgwang-myeon, Gijan-gun, Busan 619-912, Republic of Korea ) , Kim, Ki-Young (Glucan Corp. No. 305 Marine Bio-Industry Development Center, Hoenggye-ri 27, Ilgwang-myeon, Gijan-gun, Busan 619-912, Republic of Korea ) , Lee, Jong-Kwang (JKnutra, No. 502, 17 Joongdaero 23-gil, Songpa-ku, Seoul 138-160, Republic of Korea ) , Sohn, Jae Hak (RIS Center, IACF, Silla University, Gwaebup-dong, Sasang-gu, Busan 617-736, Republic of Korea ) , Ku, Sae-Kwang (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, 290 Yugok-dong, Gyeongsan-si, Gyeongsanbuk-do 712-715, Republic of Korea)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 12 , 2014 , 1741-427x ,

    초록

    Aim . The objective was to evaluate the synergistic effects of fermented rice extracts (FRe) on the laxative and probiotic properties of yoghurt in rats with loperamide-induced constipation. Methods. After constipation induction, yoghurt containing FRe (BFRe; 0.05%, 0.1%, or 1%) was administered orally once per day for 6 days. Results . Loperamide treatment caused marked decreases in fecal pellet numbers and water content discharged, as well as in the surface mucosal thickness of the colonic lumen, intestinal charcoal transit ratio, thickness, and number of mucous-producing goblet cells in the colonic mucosa, whereas it increased the remnant fecal pellet number and the mean diameter of the colonic lumen. However, this loperamide-induced constipation was ameliorated by treatment with FRe, yoghurt single formula, or 0.05%, 0.1%, or 1% BFRe (10 mL/kg). Additionally, the viable numbers of Lactobacillus in the cecal contents and feces were markedly higher than those in constipated rats. Moreover, greater probiotic and laxative effects were detected in BFRe-treated rats than in rats treated with equivalent doses of yoghurt or FRe single formula. Conclusion . The results suggest that addition of FRe to liquid yoghurt will enhance the probiotic and beneficial laxative effects of yoghurt in the digestive tract, without causing side effects.

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  3. [해외논문]   Inhibitory Effect of Sihuangxiechai Decoction on Ovalbumin-Induced Airway Inflammation in Guinea Pigs  

    Huang, Xue Ping (Department of Radiology, Affiliated Hospital of Weifang Medical University, No. 2428, Yuhe Street, Weifang, Shandong 261031, China ) , Tao, En Xue (Universtiy Hospital of Weifang Medical University, Weifang, Shandong 261053, China ) , Feng, Zhan Qin (College of Pharmacy and Biological Science, Weifang Medical University, No. 7166, Baotong West Street, Weifang, Shandong 261053, China ) , Yang, Zhao Lu (Department of Radiology, Affiliated Hospital of Weifang Medical University, No. 2428, Yuhe Street, Weifang, Shandong 261031, China ) , Zhang, Wei Fen (College of Pharmacy and Biological Science, Weifang Medical University, No. 7166, Baotong West Street, Weifang, Shandong 261053, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 8 , 2014 , 1741-427x ,

    초록

    The aim of this study was to investigate the effect of sihuangxiechai decoction on asthmatic Guinea pig model which was sensitized by intraperitoneal (i.p.) injection of ovalbumin (OVA) and challenged by OVA inhalation to induce chronic airway inflammation. Differential cell counts of cytospins were performed after staining with Giemsa solution. The quantity of leukocytes and its classification in bronchoalveolar lavage fluid (BALF) and blood were evaluated by blood cell analyzer and microscope. Histological analysis of the lung was performed by hematoxylin and eosin (H&E) staining. The levels of interleukin-4 (IL-4) and tumor necrosis factor-alpha (TNF- α ) in BALF and serum were detected by radioimmunoassay (RIA). The total number of leukocytes in BALF and blood has no significant difference between Sihuangxiechaitang decoction treated group and dexamethasone (DXM) treated group but was significantly lower than those of asthma group. The percentage of eosinophils in lung tissues of sihuangxiechai decoction treated group was significantly lower than that of asthma group. The results demonstrated that the levels of IL-4 and TNF- α in the sihuangxiechai decoction treated group were significantly reduced compared with the asthma group. In conclusion, these findings demonstrate that sihuangxiechai decoction has a protective effect on OVA-induced asthma in reducing airway inflammation and airway hyperresponsiveness (AHR) in a Guinea pig model and may be useful as an adjuvant therapy for the treatment of bronchial asthma.

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  4. [해외논문]   The Effect of theKampoMedicine Yokukansan on Preoperative Anxiety and Sedation Levels  

    Arai, Young-Chang (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Kawanishi, Jun (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Sakakima, Yoshikazu (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Sueoka, Satoshi (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Ito, Akihiro (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Tawada, Yusuke (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Maruyama, Yuki (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Banno, Shinya (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Takayama, Hitomi (Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan ) , Nishihara, Makoto (Multidisciplinary Pain Centre, School of Medicine, Aichi Medical University, 21 Karimata, Nagakutecho, Aichigun, Aichi 480-1195, Japan ) , Kawai, Takashi (Multidisciplinary Pain Centre, School of Medicine, Aichi Medical University, 21 Karimata, Nagakutecho, Aichigun, Aichi 480-1195, Japan ) , Ikemoto, Tatsunori (Multidisciplinary Pain Centre, School of Medicine, Aichi Medical University, 21 Karimata, Nagakutecho, Ai)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 4 , 2014 , 1741-427x ,

    초록

    Background . Preoperative anxiety can lead to unfavorable physiological response such as tachycardia and hypertension. Prevention of preoperative anxiety improves surgical outcome and decreases inpatient stay. Yokukansan is one of prescriptions in Kampo , traditional Japanese herbal medicine, and is known to exert anxiolytic effects. The aim of the present study was to compare the effects of diazepam and Yokukansan on preoperative anxiety, salivary amylase activity, and sedation levels. Methods . Seventy American Society of Anesthesiologists physical status I or II patients presenting for hemicolectomy under general anesthesia combined with epidural anesthesia were enrolled. The Diazepam group received diazepam 5 mg orally and the Yokukansan group received Yokukansan 2.5 g orally. Results . Although levels of anxiety and salivary amylase activity were not different between the two groups, the modified Observer's Assessment of Alertness/Sedation Scale of the Yokukansan group was significantly higher compared to that of the Diazepam group. Conclusion . Yokukansan alleviated preoperative anxiety without undesirable sedation, when compared with diazepam.

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  5. [해외논문]   Patterns of Complementary and Alternative Medicine Use, Perceived Benefits, and Adverse Effects among Adult Users in Enugu Urban, Southeast Nigeria  

    Okoronkwo, Ijeoma (Department of Nursing Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria ) , Onyia-pat, Jane-lovena (Department of Nursing Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria ) , Okpala, Pat (Department of Nursing Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria ) , Agbo, Mary-Ann (Department of Nursing Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria ) , Ndu, Afam (Department of Nursing Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 6 , 2014 , 1741-427x ,

    초록

    The use of complementary and alternative medicine (CAM) is now on the increase. Evidence from studies carried out globally has established that CAM use is very common and varies among populations. This study investigated patterns of CAM use, perceived benefits, and associated harm with CAM use among adults. A cross-sectional study was conducted in three local government areas of Enugu urban, Southeast Nigeria. An interviewer-administered questionnaire was used to collect data from all consenting adult participants aged between 18 and 65 years. Of the 732 participants interviewed, 62.8% were females while 37.2% were males. Majority (84.7%) of the participants had used CAM at one time or another. The most commonly used CAM product was the biological products, followed by spiritual therapy. The major route of administration for CAM products was oral and about 40% of the participants combined CAM with conventional medicine. Majority (78.6%) of CAM users benefited from CAM products after using them while a few complained of adverse reactions. As CAM is gaining widespread acceptance and use, there is need for clinical trial on the benefits and adverse effects associated with the use of CAM to facilitate proof of efficacy and safety of the products.

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  6. [해외논문]   Ultrasound-Guided Miniscalpel-Needle Release versus Dry Needling for Chronic Neck Pain: A Randomized Controlled Trial  

    Zheng, Yongjun , Shi, Dongping , Wu, Xiaotong , Gu, Minghong , Ai, Zisheng , Tang, Kun , Ye, Le , Wang, Xiangrui
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 8 , 2014 , 1741-427x ,

    초록

    Objective . To compare ultrasound-guided miniscalpel-needle (UG-MSN) release versus ultrasound-guided dry needling (UG-DN) for chronic neck pain. Methods . A total of 169 patients with chronic neck pain were randomized to receive either UG-MSN release or UG-DN. Before treatment and at 3 and 6 months posttreatment, pain was measured using a 10-point visual analogue scale (VAS). Neck function was examined using the neck disability index. Health-related quality of life was examined using the physical component score (PCS) and mental component score (MCS) of the SF-36 health status scale. Results . Patients in the UG-MSN release had greater improvement on the VAS (by 2 points at 3 months and 0.9 points at 6 months) versus in the UG-DN arm; (bothP Conclusion . UG-MSN release was superior to UG-DN in reducing pain intensity and neck disability in patients with chronic neck pain and was not associated with severe complications. The procedural aspects in the two arms were identical; however, we did not verify the blinding success. As such, the results need to be interpreted with caution.

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  7. [해외논문]   Cognitive-Enhancing Effect of Steamed and FermentedCodonopsis lanceolata: A Behavioral and Biochemical Study  

    Weon, Jin Bae (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea ) , Yun, Bo-Ra (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea ) , Lee, Jiwoo (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea ) , Eom, Min Rye (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea ) , Ko, Hyun-Jeong (Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea ) , Lee, Hyeon Yong (Department of Teaics, Seowon University, Cheongju 361-742, Republic of Korea ) , Park, Dong-Sik (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration, Suwon 441-853, Republic of Korea ) , Chung, Hee-Chul (Newt) , Chung, Jae Youn , Ma, Choong Je
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 9 , 2014 , 1741-427x ,

    초록

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment. Codonopsis lanceolata ( C. lanceolata ) has been employed clinically for lung inflammatory diseases such as asthma, tonsillitis, and pharyngitis. The present study was undertaken to evaluate the effect of fermented C. lanceolata (300, 500, and 800 mg/kg) on learning and memory impairment induced by scopolamine by using the Morris water maze and passive avoidance tests. To elucidate possible mechanism of cognitive-enhancing activity, we measured acetylcholinesterase (AchE) activity, brain-derived neurotrophic factor (BDNF), and cyclic AMP response element-binding protein (CREB) expression in the brain of mice. Administration of fermented C. lanceolata (800 mg/kg) led to reduced scopolamine-induced memory impairment in the Morris water maze and passive avoidance tests. Accordingly, the administration of fermented C. lanceolata inhibited AchE activity. Interestingly, the level of CREB phosphorylation and BDNF expression in hippocampal tissue of scopolamine-treated mice was significantly increased by the administration of fermented C. lanceolata . These results indicate that fermented C. lanceolata can ameliorate scopolamine-induced memory deficits in mouse and may be an alternative agent for the treatment of AD.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Differential Effects ofNaja naja atraVenom on Immune Activity  

    Kou, Jian-Qun (Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases (BM2013003), Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou 215123, China ) , Han, Rong (Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases (BM2013003), Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou 215123, China ) , Xu, Yin-Li (Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases (BM2013003), Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou 215123, China ) , Ding, Xiao-Lan (Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases (BM2013003), Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou 215123, China ) , Wang, Shu-Zhi (Jian) , Chen, Cao-Xin , Ji, Hong-Zhang , Ding, Zhi-Hui , Qin, Zheng-Hong
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 12 , 2014 , 1741-427x ,

    초록

    Previous studies reported that Naja naja atra venom (NNAV) inhibited inflammation and adjuvant arthritis. Here we investigated the role of NNAV in regulation of immune responses in mice. Oral administration of NNAV to normal mice showed significant increase in natural killer cell activity, B lymphocyte proliferation stimulated by lipopolysaccharides, and antibody production in response to sheep red blood cells. Meanwhile, NNAV markedly decreased T lymphocyte proliferation stimulated by concanavalin A, arrested the cell cycle at G0/G1phase, and suppressed CD4 and CD8 T cell divisions. Furthermore, NNAV inhibited the dinitrofluorobenzene-induced delayed-type hypersensitivity reaction. This modulation of immune responses may be partly attributed to the selective increase in Th1 and Th2 cytokines (IFN- γ , IL-4) secretion and inhibition of Th17 cytokine (IL-17) production. In dexamethasone-induced immunosuppressed mice, NNAV restored the concentration of serum IgG and IgM, while decreasing the percentage of CD4 and CD8 T-cell subsets. These results indicate that NNAV enhances the innate and humoral immune responses while inhibiting CD4 Th17 and CD8 T cell actions, suggesting that NNAV could be a potential therapeutic agent for autoimmune diseases.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Valerian: No Evidence for Clinically Relevant Interactions  

    Kelber, Olaf (Working Group Efficacy, Safety and Interactions of Kooperation Phytopharmaka GbR, Plittersdorfer Straße 218, 53173 Bonn, Germany ) , Nieber, Karen (Working Group Efficacy, Safety and Interactions of Kooperation Phytopharmaka GbR, Plittersdorfer Straße 218, 53173 Bonn, Germany ) , Kraft, Karin (Working Group Efficacy, Safety and Interactions of Kooperation Phytopharmaka GbR, Plittersdorfer Straße 218, 53173 Bonn, Germany)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 8 , 2014 , 1741-427x ,

    초록

    In recent popular publications as well as in widely used information websites directed to cancer patients, valerian is claimed to have a potential of adverse interactions with anticancer drugs. This questions its use as a safe replacement for, for example, benzodiazepines. A review on the interaction potential of preparations from valerian root ( Valeriana officinalis L. root) was therefore conducted. A data base search and search in a clinical drug interaction data base were conducted. Thereafter, a systematic assessment of publications was performed. Seven in vitro studies on six CYP 450 isoenzymes, on p-glycoprotein, and on two UGT isoenzymes were identified. However, the methodological assessment of these studies did not support their suitability for the prediction of clinically relevant interactions. In addition, clinical studies on various valerian preparations did not reveal any relevant interaction potential concerning CYP 1A2, 2D6, 2E1, and 3A4. Available animal and human pharmacodynamic studies did not verify any interaction potential. The interaction potential of valerian preparations therefore seems to be low and thereby without clinical relevance. We conclude that there is no specific evidence questioning their safety, also in cancer patients.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Adverse Events of Auricular Therapy: A Systematic Review  

    Tan, Jing-Yu (School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong ) , Molassiotis, Alexander (School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong ) , Wang, Tao (The Second Affiliated People's Hospital, Fujian University of Traditional Chinese Medicine, No. 13 Hudong Road, Gulou District, Fuzhou 350003, China ) , Suen, Lorna K. P. (School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 1 - 20 , 2014 , 1741-427x ,

    초록

    The aim of this study was to systematically evaluate the literature on adverse events associated with auricular therapy (AT). Case reports, case series, surveys, and all types of clinical trials reporting adverse events of AT were included. Relevant articles were mainly retrieved from 13 electronic databases and seven Chinese journals on complementary medicine. AT-related adverse events were reported in 32 randomized controlled trials, five uncontrolled clinical trials, four case reports, and two controlled clinical trials. For auricular acupuncture, the most frequently reported adverse events were tenderness or pain at insertion, dizziness, local discomfort, minor bleeding and nausea, and so forth. For auricular acupressure, local skin irritation and discomfort, mild tenderness or pain, and dizziness were commonly reported. Skin irritation, local discomfort, and pain were detected in auricular electroacupuncture, and minor infection was identified in auricular bloodletting therapy. Most of these events were transient, mild, and tolerable, and no serious adverse events were identified. Our findings provide preliminary evidence that AT is a relatively safe approach. Considering the patient's safety, prospective or retrospective surveys are needed in future research to gather practitioner-reported and patient-reported adverse events on AT, and the quality of adverse events reporting in future AT trials should be improved.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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