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Evidence-based Complementary and Alternative Medic... 760건

  1. [해외논문]   Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference  

    Zhao, ZhengLin , Kim, YoungWoo , Yang, YuPeng , Zhang, Jie , Jung, Ji Yun , Chang, Suchan , Cho, Il Je , Zhou, FuBo , Zhao, JunChang , Lee, Bong Hyeo , Yang, Chae Ha , Kim, Sang Chan , Zhao, RongJie
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 152063 , 2014 , 1741-427x ,

    초록

    Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine-(METH-) induced locomotor sensitization and conditioned place preference (CPP). A cohort of rats was treated with METH (1 mg/kg/day) for 6 consecutive days, subjected to 6 days of withdrawal, and then challenged with the same dose of METH to induce locomotor sensitization; during the withdrawal period, the rats were administered MEGR (60 or 180 mg/kg/day). A separate cohort of rats was treated with either METH or saline every other day for 6 days in METH-paired or saline-paired chambers, respectively, to induce CPP. These rats were also administered MEGR (180 mg/kg) prior to every METH or CPP expression test. Pretreatment with MEGR (60 and 180 mg/kg/day) attenuated the expression of METH-induced locomotor sensitization dose-dependently, and 180 mg/kg MEGR significantly inhibited the development and expression of METH-induced CPP. Furthermore, administration of a selective GABAb receptor antagonist (SCH50911) prior to MEGR treatment effectively blocked the inhibitory effects of MEGR on locomotor sensitization, but not CPP. These results suggest that Glycyrrhizae Radix blocked repeated METH-induced behavioral changes via GABAb receptors.

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  2. [해외논문]   Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference  

    Zhao, ZhengLin (Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China ) , Kim, Young Woo (Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China ) , Yang, YuPeng (The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China ) , Zhang, Jie (Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China ) , Jung, Ji Yun (Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea ) , Chang, Suchan (Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea ) , Cho, Il Je (Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea ) , Zhou, FuBo (Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China ) , Zhao, JunChang (Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin D) , Lee, Bong Hyeo , Yang, Chae Ha , Kim, Sang Chan , Zhao, RongJie
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 152063 , 2014 , 1741-427x ,

    초록

    Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and conditioned place preference (CPP). A cohort of rats was treated with METH (1 mg/kg/day) for 6 consecutive days, subjected to 6 days of withdrawal, and then challenged with the same dose of METH to induce locomotor sensitization; during the withdrawal period, the rats were administered MEGR (60 or 180 mg/kg/day). A separate cohort of rats was treated with either METH or saline every other day for 6 days in METH-paired or saline-paired chambers, respectively, to induce CPP. These rats were also administered MEGR (180 mg/kg) prior to every METH or CPP expression test. Pretreatment with MEGR (60 and 180 mg/kg/day) attenuated the expression of METH-induced locomotor sensitization dose-dependently, and 180 mg/kg MEGR significantly inhibited the development and expression of METH-induced CPP. Furthermore, administration of a selective GABAb receptor antagonist (SCH50911) prior to MEGR treatment effectively blocked the inhibitory effects of MEGR on locomotor sensitization, but not CPP. These results suggest that Glycyrrhizae Radix blocked repeated METH-induced behavioral changes via GABAb receptors.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Chemical Composition, Antioxidant and Antimicrobial Activities of Thymus capitata Essential Oil with Its Preservative Effect against Listeria monocytogenes Inoculated in Minced Beef Meat  

    El Abed, Nariman (Laboratory of Protein Engineering and Bioactive Molecules (LIP-MB), Institut National de Sciences Appliquées et de Technologie (INSAT), BP 676, 1080 Tunis Cedex, Tunisia ) , Kaabi, Belhassen (Laboratoire d'Epidémiologie et d'Ecologie des Parasites, Institut Pasteur de Tunis, BP 74, 1002 Tunis Belvédère, Tunisia ) , Smaali, Mohamed Issam (Laboratory of Protein Engineering and Bioactive Molecules (LIP-MB), Institut National de Sciences Appliquées et de Technologie (INSAT), BP 676, 1080 Tunis Cedex, Tunisia ) , Chabbouh, Meriem (Institut National Agronomique de Tunisie, 1002 Tunis, Tunisia ) , Habibi, Kamel (Institut Supérieur des Etudes Technologiques de Zaghouan, 1121 Mograne, Tunisia ) , Mejri, Mondher (Institut Supérieur des Etudes Technologiques de Zaghouan, 1121 Mograne, Tunisia ) , Marzouki, Mohamed Nejib (Laboratory of Protein Engineering and Bioactive Molecules (LIP-MB), Institut National de Sciences Appliquées et de Technologie (INSAT), BP 676, 1080 Tunis Cedex, Tunisia ) , Ben Hadj Ahmed, Sami (Laboratory of Protein Engineering and Bioactive Molecules (LIP-MB), Institut)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 152487 , 2014 , 1741-427x ,

    초록

    The chemical composition, antioxidant and antimicrobial activities, and the preservative effect of Thymus capitata essential oil against Listeria monocytogenes inoculated in minced beef meat were evaluated. The essential oil extracted was chemically analyzed by gas chromatography-mass spectrometry. Nineteen components were identified, of which carvacrol represented (88.89%) of the oil. The antioxidant activity was assessed in vitro by using both the DPPH and the ABTS assays. The findings showed that the essential oil exhibited high antioxidant activity, which was comparable to the reference standards (BHT and ascorbic acid) with IC 50 values of 44.16 and 0.463 μ g/mL determined by the free-radical scavenging DPPH and ABTS assays, respectively. Furthermore, the essential oil was evaluated for its antimicrobial activity using disc agar diffusion and microdilution methods. The results demonstrated that the zone of inhibition varied from moderate to strong (15–80 mm) and the minimum inhibition concentration values ranged from 0.32 to 20 mg/mL. In addition, essential oil evaluated in vivo against Listeria monocytogenes showed clear and strong inhibitory effect. The application of 0.25 or 1% (v/w) essential oil of T. capitata to minced beef significantly reduced the L. monocytogenes population when compared to those of control samples ( P-value

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Protective Effect of Danhong Injection on Acute Hepatic Failure Induced by Lipopolysaccharide and D-Galactosamine in Mice  

    Wang, Ying (Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjin 300193, China ) , Gao, Li-Na (Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjin 300193, China ) , Cui, Yuan-Lu (Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjin 300193, China ) , Jiang, Heng-Li (Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjin 300193, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 153902 , 2014 , 1741-427x ,

    초록

    Acute hepatic failure (AHF), which leads to an extremely high mortality rate, has become the focus of attention in clinic. In this study, Danhong injection (DHI) was investigated to evaluate the preventive and protective effect on AHF induced by lipopolysaccharide (LPS) and D-galactosamine (GalN) in mice. For AHF induction, ICR mice were intraperitoneally injected with D-GalN (700 mg/kg) and LPS (20 μ g/kg). DHI was administrated twice, at 12 and 1 h, respectively, before D-GalN/LPS injection. After stimulation with D-GalN/LPS for 1 and 6 h, serum and livers were collected for analysis. We found that mice administrated with DHI displayed a higher survival rate, lower serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), glutathione S-transferase (GST), and tumor necrosis factor (TNF)- α . DHI inhibited the elevations of hepatic lipid peroxidation (malondialdehyde), caspase-8 activity, and mRNA expression levels of inflammatory cytokines (interleukin-1 β and interleukin-6) increased by D-GalN/LPS in the liver. Furthermore, liver histopathological analysis indicated that the DHI group showed markedly fewer apoptotic (TUNEL positive) cells and less pathological changes than those in the AHF model group. These results provide a novel insight into the pharmacological actions of DHI as a potential candidate for treating AHF.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   A 3-Arm, Randomized, Controlled Trial of Heat-Sensitive Moxibustion Therapy to Determine Superior Effect among Patients with Lumbar Disc Herniation  

    Chen, Rixin (The Affiliated Hospital with Jiangxi University of TCM, No. 445 Bayi Avenue, Nanchang 330006, China ) , Chen, Mingren (The Affiliated Hospital with Jiangxi University of TCM, No. 445 Bayi Avenue, Nanchang 330006, China ) , Su, Tongsheng (Shanxi TCM Hospital, Xian 710003, China ) , Zhou, Meiqi (The First Affiliated Hospital with Anhui University of TCM, Hefei 230031, China ) , Sun, Jianhua (Jiangsu TCM Hospital, Nanjing 210029, China ) , Xiong, Jun (The Affiliated Hospital with Jiangxi University of TCM, No. 445 Bayi Avenue, Nanchang 330006, China ) , Chi, Zhenhai (The Affiliated Hospital with Jiangxi University of TCM, No. 445 Bayi Avenue, Nanchang 330006, China ) , Xie, Dingyi (The Affiliated Hospital with Jiangxi University of TCM, No. 445 Bayi Avenue, Nanchang 330006, China ) , Zhang, Bo (The Affiliated Hospital with Jiangxi University of TCM, No. 445 Bayi Avenue, Nanchang 330006, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 154941 , 2014 , 1741-427x ,

    초록

    Systematic reviews of moxibustion for LDH have identified ponderable evidence, especially for heat-sensitive moxibustion (HSM). Therefore, we designed and carried out the large sample trial to evaluate it. 456 patients were recruited from 4 centers in China and were randomly divided into three groups by the ratio of 1 : 1 : 1 to HSM (152) group, conventional moxibustion (152) group, and conventional drug plus acupuncture (152) group. Compared with usual care, there was a statistically significant reduction in mean M-JOA score at 2 weeks and 6 months for HSM (3.8 ± 2.6 versus 8.5 ± 2.9; 3.7 ± 2.2 versus 10.1 ± 2.9) and conventional moxibustion (7.9 ± 3.0 versus 8.5 ± 2.9; 8.9 ± 3.1 versus 10.1 ± 2.9). Compared with conventional moxibustion group, HSM group showed greater improvement in all the outcomes. The mean dose of moxibustion was 41.13 ± 5.26 (range 21–60) minutes in the HSM group. We found that HSM was more effective in treating patients with LDH, compared with conventional moxibustion and conventional drug plus acupuncture. This finding indicated that the application of moxibustion on the heat-sensitive points is a good moxibustion technique in treating disease.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Finding Inhibitors of Mutant Superoxide Dismutase-1 for Amyotrophic Lateral Sclerosis Therapy from Traditional Chinese Medicine  

    Huang, Hung-Jin (Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan ) , Chang, Tung-Ti (School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan ) , Chen, Hsin-Yi (Department of Biomedical Informatics, Asia University, Taichung 41354, Taiwan ) , Chen, Calvin Yu-Chian (Department of Biomedical Informatics, Asia University, Taichung 41354, Taiwan)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 156276 , 2014 , 1741-427x ,

    초록

    Superoxide dismutase type 1 (SOD1) mutations cause protein aggregation and decrease protein stability, which are linked to amyotrophic lateral sclerosis (ALS) disease. This research utilizes the world's largest traditional Chinese medicine (TCM) database to search novel inhibitors of mutant SOD1, and molecular dynamics (MD) simulations were used to analyze the stability of protein that interacted with docked ligands. Docking results show that hesperidin and 2,3,5,4′-tetrahydroxystilbene-2-O- β -D-glucoside (THSG) have high affinity to mutant SOD1 and then dopamine. For MD simulation analysis, hesperidin and THSG displayed similar value of RMSD with dopamine, and the migration analysis reveals stable fluctuation at the end of MD simulation time. Interestingly, distance between the protein and ligand has distinct difference, and hesperidin changes the position from initial binding site to the other place. In flexibility of residues analysis, the secondary structure among all complexes does not change, indicating that the structure are not affect ligand binding. The binding poses of hesperidin and THSG are similar to dopamine after molecular simulation. Our result indicated that hesperidin and THSG might be potential lead compound to design inhibitors of mutant SOD1 for ALS therapy.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation  

    El-Houri, Rime B. (Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark ) , Kotowska, Dorota (Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark ) , Olsen, Louise C. B. (Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark ) , Bhattacharya, Sumangala (Department of Food Science, Aarhus University, Blichers Allé, P.O. Box 50, 8830 Tjele, Denmark ) , Christensen, Lars P. (Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark ) , Grevsen, Kai (Department of Food Science, Aarhus University, Kirstinebjergvej 10, 5792 Aarslev, Denmark ) , Oksbjerg, Niels (Department of Food Science, Aarhus University, Blichers Allé, P.O. Box 50, 8830 Tjele, Denmark ) , Færgeman, Nils (Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark ) , Kristiansen, Karsten (Department of Biology, University of Copenhagen, Ole Maal) , Christensen, Kathrine B.
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 156398 , 2014 , 1741-427x ,

    초록

    Dichloromethane and methanol extracts of seven different food and medicinal plants were tested in a screening platform for identification of extracts with potential bioactivity related to insulin-dependent glucose uptake and fat accumulation. The screening platform included a series of in vitro bioassays, peroxisome proliferator-activated receptor (PPAR) γ -mediated transactivation, adipocyte differentiation of 3T3-L1 cell cultures, and glucose uptake in both 3T3-L1 adipocytes and primary porcine myotubes, as well as one in vivo bioassay, fat accumulation in the nematode Caenorhabditis elegans . We found that dichloromethane extracts of aerial parts of golden root ( Rhodiola rosea ) and common elder ( Sambucus nigra ) as well as the dichloromethane extracts of thyme ( Thymus vulgaris ) and carrot ( Daucus carota ) were able to stimulate insulin-dependent glucose uptake in both adipocytes and myotubes while weekly activating PPAR γ without promoting adipocyte differentiation. In addition, these extracts were able to decrease fat accumulation in C. elegans . Methanol extracts of summer savory ( Satureja hortensis ), common elder, and broccoli ( Brassica oleracea ) enhanced glucose uptake in myotubes but were not able to activate PPAR γ , indicating a PPAR γ -independent effect on glucose uptake.

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  8. [해외논문]   Neuroprotective Effect of a Formula, Moschus Combined with Borneolum Synthcticum, from Traditional Chinese Medicine on Ischemia Stroke in Rats  

    Xia, Xin-hua (The First Hospital Affiliated to Guangzhou Medical University, Guangzhou 510120, China ) , Li, Qiang (The Heart Center, The First Hospital Affiliated to Lanzhou University, Lanzhou 710030, China ) , Liu, Mei (School of Chinese Material Medical of Guangzhou University of Chinese Medicine, 232 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong 510006, China)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 157938 , 2014 , 1741-427x ,

    초록

    Moschus compatible with borneolum synthcticum is a well-known herb pair in Traditional Chinese Medicine and the present study aims to assess the neuroprotective effect of a formula composed of this herb pair on ischemia stroke in rats. The middle cerebral artery occlusion model of focal cerebral ischemia in rat was performed by using intraluminal suture method. The behavioral scores, infarct volume, and neuron ultrastructure of model and formula-treated rats were investigated after the 2 h of ischemia and 24 h of reperfusion. Meanwhile the expression levels of caspase-3, caspase-9, Bcl-2, and Bax were measured by western blot analysis. The formula treatment showed obvious neuroprotective effect according to significant decrease of the neurological scores ( P P P P

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Effect of Achyranthes bidentata Blume on 3T3-L1 Adipogenesis and Rats Fed with a High-Fat Diet  

    Oh, Sang Deog (Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea ) , Kim, Mihyun (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea ) , Min, Byung-Il (Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea ) , Choi, Gi Soon (Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea ) , Kim, Sun-Kwang (Acupuncture & Meridian Science Research Center, Kyung Hee University, Seoul, Republic of Korea ) , Bae, Hyunsu (Department of Physiology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea ) , Kang, Chulhun (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea ) , Kim, Deok-Gon (Department of Oriental Pediatrics, Kyung Hee Medical Center, Kyung Hee University, Seoul, Republic of Korea ) , Park, Byoung-Jin (Department of Family Medicine, CHA University School of Medicine, Seoul, Republic of Korea ) , Kim, Chang Keun (Department of East-West Medicine, Graduat)
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 158018 , 2014 , 1741-427x ,

    초록

    The present study investigated the antiobesity effect of Achyranthes bidentata Blume root water extract in a 3T3-L1 adipocyte differentiation model and rats fed with a high-fat diet. To investigate the effect of Achyranthes bidentata Blume on adipogenesis in vitro , differentiating 3T3-L1 cells in adipocyte-induction media were treated every two days with Achyranthes bidentata Blume at various concentrations (1 to 25 μ g/mL) for eight days. We found that Achyranthes bidentata Blume root inhibited 3T3-L1 adipocyte differentiation without affecting cell viability, and Western blot analysis revealed that phospho-Akt expression was markedly decreased, whereas there was no significant change in perilipin expression. Furthermore, administration of Achyranthes bidentata Blume root (0.5 g/kg body weight for six weeks) to rats fed with a high-fat diet significantly reduced body weight gain without affecting food intake, and the level of triglyceride was significantly decreased when compared to those in rats fed with only a high-fat diet. These results suggest that Achyranthes bidentata Blume root water extract could have a beneficial effect on inhibition of adipogenesis and controlling body weight in rats fed with a high-fat diet.

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  10. [해외논문]   Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain  

    Li, Qian (Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, 138 Yi-Xue-Yuan Road, Shanghai 200032, China ) , Yue, Na (Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, 138 Yi-Xue-Yuan Road, Shanghai 200032, China ) , Liu, Shen-Bin (Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, 138 Yi-Xue-Yuan Road, Shanghai 200032, China ) , Wang, Zhi-Fu (Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University,) , Mi, Wen-Li , Jiang, Jian-Wei , Wu, Gen-Cheng , Yu, Jin , Wang, Yan-Qing
    Evidence-based Complementary and Alternative Medicine : eCAM v.2014 ,pp. 158987 , 2014 , 1741-427x ,

    초록

    Growing evidence indicates that chronic neuropathic pain is frequently accompanied by an array of psychiatric diseases, such as depression and anxiety. Electroacupuncture (EA), as one therapy of traditional Chinese medicine, has displayed potent antidepressant-like effects in numerous clinical studies. The present study was designed to examine the possible effects of EA on the depressive and anxiety disorders induced by neuropathic pain. A classic rat model of neuropathic pain was produced by chronic constriction injury (CCI) of the sciatic nerve. EA was performed on acupoints “Bai-Hui” (GV20) and unilateral “Yang-Ling-Quan” (GB34). The antidepressive and anxiolytic effects of EA treatment were analyzed using the forced swimming test (FST) and the elevated plus maze (EPM) test, respectively. CCI resulted in remarkable depression- and anxiety-like behaviors, whereas the chronic EA treatment significantly improved the behavioral deficits of CCI rats. Moreover, the phosphorylation level of the NMDA receptor type 1 (NR1) subunit was decreased in the hippocampus of CCI rats. Intriguingly, continuous EA treatment effectively blocked this decrease in the levels of pNR1. These results suggested that EA has antidepressive and anxiolytic effects on rats with neuropathic pain and that this might be associated with restoring the phosphorylation of NR1 in the hippocampus.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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