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Journal of the European Academy of Dermatology and... 77건

  1. [해외논문]   A systematic review of worldwide epidemiology of psoriasis   SCIE

    Michalek, I.M. (Medical University of Warsaw, Warsaw, Poland) , Loring, B. (Department for Management of Noncommunicable Diseases, Disability, Violence and Injury Prevention, World Health Organization, Geneva 27, Switzerland) , John, S.M. (Department of Dermatology, Environmental Medicine, Health Theory, University of Osnabrueck, Osnabruck, Germany)
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 205 - 212 , 2017 , 0926-9959 ,

    초록

    Abstract To inform the WHO Global report on psoriasis, a new comprehensive worldwide systematic review of the epidemiology of psoriasis was undertaken. The aim of this study was to systematically review the worldwide literature regarding the epidemiology of psoriasis, including prevalence and incidence, in adults and in children. A search of 15 electronic medical databases was performed. Using a rigorous systematic protocol, eligible articles were analysed. No language, regional or temporal restrictions were applied. A total of 76 study observations met all eligibility criteria and were included in the systematic review. The estimates of the prevalence of psoriasis in adults ranged from 0.51% to 11.43%, and in children from 0% to 1.37%. Psoriasis is a common disease, occurring more frequently with advancing age. Limited data on the epidemiology of psoriasis are available. The available prevalence data come from only 20 countries, meaning there are huge geographic gaps in knowledge, especially from low‐ and middle‐income settings.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Clear or almost clear skin improves the quality of life in patients with moderate‐to‐severe psoriasis: a systematic review and meta‐analysis   SCIE

    Puig, L. (Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona Medical School, Barcelona, Spain) , Thom, H. (School of Social and Community Medicine, University of Bristol, Bristol, UK) , Mollon, P. (Global Patient Access, Novartis Pharma AG, Basel, Switzerland) , Tian, H. (Global Medical Affairs, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA) , Ramakrishna, G.S. (Patient Access Services, Novartis Healthcare Private Limited, Hyderabad, India)
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 213 - 220 , 2017 , 0926-9959 ,

    초록

    Abstract Psoriasis Area and Severity Index (PASI) 75 response is currently considered the gold standard for assessing treatment efficacy in moderate‐to‐severe psoriatic patients. PASI 90 response denotes better clinical improvement compared to PASI 75. Very few studies have assessed if a greater PASI clinical response is associated with greater improvements in Dermatology Life Quality Index (DLQI). A systematic review and meta‐analysis was performed to assess the association between PASI response and DLQI. The study was conducted to assess whether greater improvement in PASI scores from PASI 75–89 to PASI 90 is associated with greater Quality of life (QoL) improvements, specifically DLQI scores. Systematic searches were conducted in MEDLINE, EMBASE and Cochrane Library to identify studies evaluating biologic interventions in adult moderate‐to‐severe psoriasis patients reporting PASI response and their corresponding DLQI change from baseline score. The quality of evidence was assessed through Jadad score for randomized controlled trials and Downs and Black's checklist for observational studies. Meta‐analysis estimated change from baseline in DLQI for PASI 75–89 responders to be 78% (95% credible intervals [CrI]: 75–82%) and for PASI 90 responders to be 90% (95% CrI: 88–93%). This implies 12% greater improvement in DLQI score for PASI 90 responders compared with PASI 75–89 responders. In addition, the meta‐analysis also showed a statistically significant difference in DLQI score of 0/1 between PASI 75‐89 and PASI 90 responders (45% [95% Crl]; 41.0–50.0% and 73% [95% Crl]; 70.0–76.0%), respectively, Bayesian P

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Treatment of necrobiotic xanthogranuloma – a systematic review   SCIE

    Miguel, D. (Department of Dermatology, University Hospital, Jena, Germany) , Lukacs, J. (Department of Dermatology, University Hospital, Jena, Germany) , Illing, T. (Department of Dermatology, University Hospital, Jena, Germany) , Elsner, P. (Department of Dermatology, University Hospital, Jena, Germany)
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 221 - 235 , 2017 , 0926-9959 ,

    초록

    Abstract Necrobiotic xanthogranuloma (NXG) is an uncommon non‐Langerhans cell histiocytosis involving skin and extracutaneous tissues. The lesions are usually asymptomatic and commonly appear in the periorbital area. Paraproteinemia is closely associated with NXG and its pathogenesis remains unclear. NXG prognosis is poor with several treatments showing variable results. Treatment of monoclonal gammopathy with alkylating agents does not necessarily influence the activity of the skin disease and vice versa. The aim of this systematic review is to summarize all reported treatments of necrobiotic xanthogranuloma of the skin, with or without underlying malignant condition and based on articles from the PubMed database using the query ‘necrobiotic xanthogranuloma treatment’, both in English and German, about ‘human’ subjects and published between 1980 and 2014, documenting adequate treatment for NXG. Mainly individual case reports, small case series and retrospective studies were found. Treatment options include topical and systemic corticosteroids, thalidomide, high‐dose intravenous immunoglobulin (IVIG), chlorambucil, cyclophosphamide, fludarabine, rituximab, melphalan, infliximab, interferon alpha, cladribine, hydroxychloroquine, azathioprine, methotrexate, laser therapy, radiotherapy, surgery, PUVA, plasmapheresis and extracorporeal photopheresis. Randomized controlled trials and studies on long‐term outcomes after treatment were not found and are necessary to focus on in the future.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   An update on cutaneous melanoma in Turkey: evaluation of 19‐year data in a single tertiary centre and review of the literature   SCIE

    Baykal, C. (Departments of Dermatology & Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey) , Atci, T. (Departments of Dermatology & Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey) , Polat Ekinci, A. (Departments of Dermatology & Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey) , Buyukbabani, N. (Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey)
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 236 - 240 , 2017 , 0926-9959 ,

    초록

    Abstract Background Information on frequency of melanoma and its clinicopathological subtypes derived from dermatology clinics in Turkey is limited. Objective As data about melanoma show clear differences due to geographic and ethnic distribution, we scrutinized the rich data of our dermatology centre in Istanbul. Methods Consecutive patients diagnosed with melanoma in a tertiary dermatology clinic during the last 19 years were retrospectively investigated about the clinical presentation of the skin lesions during admission, frequency of subtypes and localization of the tumour. Results There were 227 patients with melanoma showing five different clinical presentations: 200 of them had totally 207 primary cutaneous melanoma (PCM) lesions, nine had PCM lesions associated with metastatic skin lesions, three presented with local recurrence, eight with only skin metastases and seven with regressed skin melanoma following systemic melanoma metastases. Histologically, 23.19% of the PCM lesions were intraepidermal ( in situ ) and Breslow thickness was less than 1 mm in 30.9% of the patients with invasive melanoma. The most common subtype was superficial spreading melanoma (SSM) (37.19%), followed by lentigo malignant melanoma (LMM) (31.4%), acral lentiginous melanoma (ALM) (19.32%) and nodular melanoma (NM) (6.76%). Head and neck region was the most common (34.78%) localization of PCM lesions. Conclusions Different clinical presentations, including various types of cutaneous melanoma metastases, were seen. However, a great proportion of our patients were relatively early diagnosed, either having an in situ or an invasive PCM with a Breslow thickness ≤1 mm. Even though SSM was the most common subtype of PCM in our series, its rate was lower compared to many European countries. Furthermore, the rate of NM subtype was also low, while LMM and ALM rates were higher in comparison to studies originating from European countries. This striking discrepancy requires further studies to explain the probable causes.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Sentinel lymph node biopsy plus wide local excision vs. wide location excision alone for primary cutaneous melanoma: a systematic review and meta‐analysis   SCIE

    Santos‐ (Dermatology II Department of Hospital Universitario Central de Asturias, Oviedo, Spain) , Juanes, J. (Pathology Department of Hospital Universitario Araba, Álava, Spain) , Ferná (Departamento de Radiodiagnóstico, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain) , ndez‐ (Dermatology II Department of Hospital Universitario Central de Asturias, Oviedo, Spain) , Vega, I. (Geisel School of Medicine at Dartmouth, Hanover, NH, USA) , Galache Osuna, C. , Coto‐ , Segura, P. , Martí , nez‐ , Camblor, P.
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 241 - 246 , 2017 , 0926-9959 ,

    초록

    Abstract Background Sentinel lymph node biopsy and wide local excision of the primary melanoma (SLNB) is now a standard staging procedure for patients with melanomas 1 mm or more in thickness, but its therapeutic benefit is not clear. Objective To determine whether there is an association between performance of SLNB and patient prognosis. Methods Studies assessing the association between performance of SLNB and patient prognosis were pooled from MEDLINE, EMBASE, PubMed, Cochrane Database of Systematic Reviews and Google Scholar. From each study, first author's last name, publication year, origin country, type of study design, characteristics of participants and the Hazard risk (HR) for melanoma specific survival (MSS) with the corresponding 95% confidence interval (95% CI) were collected. Methodological assessment of the studies was evaluated using the Newcastle‐Ottawa scale (NOS) and the ‘Risk of bias’ tool detailed in the Cochrane Handbook for Systematic Reviews of Interventions . Meta‐analyses for the global HR were performed. In addition, in order to explore the sources of heterogeneity among the studies, sensitivity analyses are also provided. Results A total of six studies with 8764 patients who had undergone SLNB and 11054 patients who had undergone wide location excision alone (WLEA) were identified for the analysis. The indicators suggest that the heterogeneity is low: τ 2 = 0; H = 1 [1; 1.74]; I 2 = 0% [0%; 66.5%]. Evidence for publication bias was not found (Egger's test P = 0.4654). The pooled MSS HR from fixed effects analysis was determined to be 0.88 (95% CI = 0.80–0.96). Conclusions Although no significant survival difference was observed in four of the six series, the pooling summary data from all the studies that deal with this issue suggested that SLNB is associated with a significantly better outcome compared with WLEA for localized melanoma.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Both short‐term and long‐term dermoscopy monitoring is useful in detecting melanoma in patients with multiple atypical nevi   SCIE

    Moscarella, E. (Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy) , Tion, I. (Unit of Dermatology, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari, Italy) , Zalaudek, I. (Department of Dermatology, Medical University of Graz, Graz, Austria) , Lallas, A. (Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy) , Kyrgidis, A. (Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy) , Longo, C. (Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy) , Lombardi, M. (Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy) , Raucci, M. (Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, R) , Satta, R. , Alfano, R. , Argenziano, G.
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 247 - 251 , 2017 , 0926-9959 ,

    초록

    Abstract Background Digital dermoscopy monitoring (DDM) is an effective strategy for melanoma detection. Two methods are currently employed. Short‐term follow‐up (STFU) for the evaluation of single, atypical lesions to detect subtle changes over a short period of time (3–6 months). Long‐term follow‐up (LTFU) is recommended for patients with multiple nevi. Although a study demonstrated that STFU improves the patients’ compliance for DDM, little remains known about the impact and reliability of STFU in this setting. Objectives The aim of this retrospective, observational study was to evaluate the impact and reliability of a schedule combining STFU and LTFU in patients with multiple atypical nevi. Methods We searched our database for all cases of patients with multiple atypical nevi occurring between 2006 and 2014. Results A total of 3823 lesions in 541 patients were dermoscopically monitored (mean number = 7 lesions per patient; median = 6 lesions; range, 2–51). In all, 264 (6.9%) lesions in 184 (34.4%) patients were excised (mean of 0.5 lesions per patient). In total, 197 (74.6%) lesions were excised at follow‐up, with melanomas representing 30.5% of lesions excised after follow‐up. A total of 30 (33.3%) melanomas were excised at baseline, 23 (25.6%) after STFU and 37 (41.1%) after LTFU. There was no difference in the number of in situ melanomas detected at baseline with those detected after follow‐up. The mean Breslow thickness of melanomas detected at baseline was higher than those detected after STFU ( P = 0.038) and LTFU ( P = 0.055). Conclusions Our study confirm that digital dermoscopy follow‐up is a valid management strategy for patients with multiple atypical nevi, with short‐term monitoring playing an effective role also in this setting of patients.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Melanoma antigens are biomarkers for ipilimumab response   SCIE

    Arenberger, P. (Department of Dermatovenereology, Third Faculty of Medicine, Charles University and Faculty Hospital of Kralovske Vinohrady, Prague, Czech Republic) , Fialova, A. (Department of Dermatovenereology, Third Faculty of Medicine, Charles University and Faculty Hospital of Kralovske Vinohrady, Prague, Czech Republic) , Gkalpakiotis, S. (Department of Dermatovenereology, Third Faculty of Medicine, Charles University and Faculty Hospital of Kralovske Vinohrady, Prague, Czech Republic) , Pavlikova, A. (Institute for Laboratory Diagnostics, Faculty Hospital of Kralovske Vinohrady, Prague, Czech Republic) , Puzanov, I. (Division of Hematology‐Oncology, Vanderbilt University Medical Center, Nashville, TN, USA) , Arenbergerova, M. (Department of Dermatovenereology, Third Faculty of Medicine, Charles University and Faculty Hospital of Kralovske Vinohrady, Prague, Czech Republic)
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 252 - 259 , 2017 , 0926-9959 ,

    초록

    Abstract Background Novel immunotherapy modalities significantly improve survival of patients with metastatic melanoma. However, CTLA‐4‐blocking monoclonal antibody ipilimumab is effective only in a small proportion of patients. Biomarkers for prediction of treatment response are indispensably needed. Objective To determine the utility of multimarker detection of circulating melanoma cells as prognostic and pharmacodynamic biomarker in patients with metastatic melanoma treated with ipilimumab. Methods Patients ( n = 62) with metastatic melanoma in unresectable stage III or metastatic stage IV treated with ipilimumab were recruited prospectively. The values of four melanoma markers on circulating cells Melan‐A, gp100, MAGE‐3 and melanoma inhibitory antigen prior to the treatment and within the therapy were compared to the data collected at baseline – after the melanoma surgery. Results The immunotherapy pretreatment marker level was found to be prognostic of overall survival; lower levels were linked to longer survival time. Moreover, longitudinal follow‐up of melanoma markers in patients treated with ipilimumab correlates with therapy response. A decline of marker levels by >30% at week 6 (in 83% of the responding subjects) to week 9 (in all responders) of ipilimumab administration was associated with response to therapy. Elevation of the tumour markers during the treatment precedes clinical progression and gives an early warning of treatment failure. Conclusion Melanoma circulating cells hold potential as predictive and pharmacodynamic biomarker of immunotherapy.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Ingenol mebutate in actinic keratosis: a clinical, videodermoscopic and immunohistochemical study   SCIE

    Bobyr, I. (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Ancona, Italy) , Campanati, A. (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Ancona, Italy) , Consales, V. (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Ancona, Italy) , Martina, E. (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Ancona, Italy) , Molinelli, E. (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Ancona, Italy) , Diotallevi, F. (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Ancona, Italy) , Brisigotti, V. (Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche Un) , Giangiacomi, M. , Ganzetti, G. , Giuliodori, K. , Offidani, A.
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 260 - 266 , 2017 , 0926-9959 ,

    초록

    Abstract Background Actinic keratosis (AK) is a cutaneous intraepithelial neoplasm that typically develops on sun‐damaged skin. The incidence of AK is increasing worldwide, and it is accepted as the most frequent pre‐malignant lesion in humans. Objectives To demonstrate that ingenol mebutate gel is effective in the treatment of actinic keratoses because of its clinical, dermoscopic, capillaroscopic, histopathological and immunohistochemical treatment outcomes. Methods Sixty individuals with multiple non‐hypertrophic AKs were enrolled into this non‐randomized, open‐label, prospective, trial. Acquisition of clinical, dermoscopic and capillaroscopic images at baseline (T0), immediately after treatment on 3 rd (trunk and/or extremities) or 4 th (scalp and/or face) day (T1), 14 days after the end of the treatment (T2) and at 60 days (T3). A subgroup of 20 patients received a cutaneous biopsy both at baseline and at T3 for histological and immunohistochemical evaluation. Results Clinical improvement was observed in 100% of cases: total clearance in 41 patients (68.3%); partial clearance in 19 patients (32.7%). After treatment, dermoscopic improvement of all non‐pigmented and pigmented AK lesions was observed. Most of the dermoscopic features disappeared with treatment. Total disappearance of specific vascular structures or significant reduction in the number and calibre of new blood vessels was capillaroscopically observed in all patients analysed ( P ≤ 0.001). The immunohistochemical expression of p63 ( P = 0.002), Ki‐67 ( P = 0.015) and VEGF ( P = 0.016) significantly decreased. Conclusions The clinical efficacy of ingenol mebutate on AKs is confirmed by its effect on angiogenesis, stem cell activity and cell proliferation in vivo .

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   A model for perception‐based identification of sensitive skin   SCIE

    Richters, R.J.H. (Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands) , Uzunbajakava, N.E. (Philips Research Eindhoven, Philips Electronics Nederland B.V., Eindhoven, The Netherlands) , Hendriks, J.C.M. (Radboud Institute for Health Sciences, Nijmegen, The Netherlands) , Bikker, J.‐ (CQM, Eindhoven, The Netherlands) , W. (Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands) , van Erp, P.E.J. (Radboud Institute for Health Sciences, Nijmegen, The Netherlands) , van de Kerkhof, P.C.M.
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 267 - 273 , 2017 , 0926-9959 ,

    초록

    Abstract Background With high prevalence of sensitive skin (SS), lack of strong evidence on pathomechanisms, consensus on associated symptoms, proof of existence of ‘general’ SS and tools to recruit subjects, this topic attracts increasing attention of research. Objective To create a model for selecting subjects in studies on SS by identifying a complete set of self‐reported SS characteristics and factors discriminatively describing it. Methods A survey ( n = 3058) was conducted, comprising questions regarding socio‐demographics, atopy, skin characteristics, personal care, degree of self‐assessed SS and subjective and objective reactions to endogenous and exogenous factors. Exploratory factor analysis on 481 questionnaires was performed to identify underlying dimensions and multivariate logistic regression to find contributing variables to the likelihood of reporting SS. Results The prevalence of SS was found to be 41%, and 56% of SS subjects reports a concomitant atopic condition. The most discriminative were the eliciting factors toiletries and emotions, and not specific skin symptoms in general. Conclusion Triggers of different origins seem to elicit SS, it is not defined by concomitant skin diseases only, suggesting existence of ‘general’ SS. A multifactorial questionnaire could be a better diagnostic than a one‐dimensional provocative test.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  10. [해외논문]   Dermatological emergencies: evolution from 2008 to 2014 and perspectives   SCIE

    Isnard, C. (Dermatology department, AP‐HP, Henri Mondor Hospital, Créteil, France) , Ingen‐ (Dermatology department, AP‐HP, Henri Mondor Hospital, Créteil, France) , Housz‐ (Dermatology department, AP‐HP, Henri Mondor Hospital, Créteil, France) , Oro, S. (Dermatology department, AP‐HP, Henri Mondor Hospital, Créteil, France) , Fardet, L. (Dermatology department, AP‐HP, Henri Mondor Hospital, Créteil, France) , Matteodo, E. (Medical information department, AP‐HP, Henri Mondor Hospital, Créteil, France) , Duval, S. (General Emergency department and Unité) , Hemery, F. (INSERM U 955 équipe 2, AP‐HP, Henri Mondor Hospital, Créteil, France) , Khellaf, M. (Dermatology department, AP‐HP, Henri Mondor Hospital, Crét) , Duong, T.‐ , A. , Chosidow, O. , Wolkenstein, P.
    Journal of the European Academy of Dermatology and Venereology : JEADV v.31 no.2 ,pp. 274 - 279 , 2017 , 0926-9959 ,

    초록

    Abstract Background Our dermatological department includes a dermatological emergency unit (DEU) whose activity has grown in recent years. Objectives An audit to characterize the activity of our DEU and its evolution in terms of medical demographics of the area. Methods We collected the following data from administrative services: number of patients consulting each year in the DEU and in the general emergency unit (GEU) of our hospital between 2008 and 2014; daily and seasonal activity of the DEU; occurrence of a second event in the department and proportion of patients from the DEU who were hospitalized and why. From the medical charts of a random sample of patients consulting in the first 15 days of January and August 2014, we studied the epidemiological profile, time to consultation and diagnoses. Data related to medical demographics (number of general practitioners and dermatologists) between 2007 and 2014 and projections were obtained. Results The activity in the DEU increased by 67% between 2008 and 2014 but remained stable in the GEU over the same period. The activity was higher on Mondays and in the summer (+30%). More than 15% of the patients were seen a second time in outpatient consultation; 1.2% were hospitalized. Infectious dermatosis was the main reason for consultation; seasonal‐disease consultations were more frequent in the summer. Less than 40% of patients consulted in the first week after disease onset. Medical demographics continually decreased since 2007 in Paris and suburbs and will continue to decrease in the next years. Conclusion The increasing activity of our DEU parallels the decrease in medical demographics in Paris. The proportion of patients hospitalized was low, in part due to specific healthcare networks implemented for some life‐threatening dermatoses independent of the DEU. A better coordination between hospital and private practitioners for managing dermatologic emergencies, taking into account the decrease in medical demographics, is warranted.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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