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GEMS 기술을 이용한 신규 위암/간암 치료제 발굴
Discovery and Development of New Gastric and Hepatic Cancer Small Molecule Therapeutics UsingGEMS Platform Technology

  • 사업명

    21C프론티어연구개발사업

  • 과제명

    GEMS 기술을 이용한 신규 위암/간암 치료제 발굴

  • 주관연구기관

    KRIBB and PTC Therapeutics

  • 연구책임자

    문영춘

  • 보고서유형

    2단계보고서

  • 발행국가

    대한민국

  • 언어

    대한민국

  • 발행년월

    2006-05

  • 과제시작년도

    2004

  • 주관부처

    과학기술부

  • 사업 관리 기관

    한국과학재단
    Korea Science and Engineering Foundtion

  • 등록번호

    TRKO201000012241

  • 과제고유번호

    1350022803

  • DB 구축일자

    2013-04-18

  • 초록 


    Three genes, OPN, TEBP/p23 and ZFP36fTTP, were selected from several lists of target genes identified by the Korea Functional Gen...

    Three genes, OPN, TEBP/p23 and ZFP36fTTP, were selected from several lists of target genes identified by the Korea Functional Genome ProJect as being physiologically important in the development of gastric and liver cancers. In the OPN project, several inhibitors of OPN gene expression have been identified and are being further characterized. Similarly, we have also identified an inhibitor of TEBP/p23 gene expression that is being assessed. Finally, a GEMS UTR reporter assay was developed for the identification of up-regulators of TTPIZFP36 gene expression and a high throughput screen has been run. We have achieved 100% of our goats for Phase
    Introduction
    Cancer is a major public health problem in the world. Globally in 2002, there were 10.9 million new cases, 6.7 million deaths, and 24.6 million persons living with cancer (within three years of diagnosis). The most commonly diagnosed cancers are lung (1.35 million), breast (1.15 million), and colorectal (1 million); the most common causes of cancer death are lung cancer (1.18 million deaths), stomach cancer (700,000 deaths), and liver cancer (598,000 deaths).


    ...


  • 목차(Contents) 

    1. 표지...1
    2. Summary...2
    3. 1. 과제현황 ...2
    4. 2. 최종목표 및 결과 ...2
    5. 3. 연구개발결과 활용 계획(기술이전 및 3단계 진입시 추진 계획 등)...21
    6. 4. Achievements and Contributions ...21
    7. 5. Conclusions .....
    1. 표지...1
    2. Summary...2
    3. 1. 과제현황 ...2
    4. 2. 최종목표 및 결과 ...2
    5. 3. 연구개발결과 활용 계획(기술이전 및 3단계 진입시 추진 계획 등)...21
    6. 4. Achievements and Contributions ...21
    7. 5. Conclusions ...22
    8. 6. Science and Technology Information ...22
    9. 7. Refrences ...23
  • 참고문헌

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