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Study on polymer models of bacterial chromosomes
Study on polymer models of bacterial chromosomes

  • 주관연구기관

    Waterloo Univ. (Ontario)

  • 연구책임자

    하배연

  • 참여연구자

    장영균   정하웅  

  • 보고서유형

    최종보고서

  • 발행국가

    대한민국

  • 언어

    대한민국

  • 발행년월

    2015-10

  • 주관부처

    미래창조과학부
    KA

  • 사업 관리 기관

    한국과학기술정보연구원
    Korea Institute of Science and Technology Information

  • 등록번호

    TRKO201600000525

  • DB 구축일자

    2016-04-16

  • 초록 


    Chapter 1
    Polymers under connement: single polymers, how they interact, and as model chromosomes

    How chromosomes are sp...

    Chapter 1
    Polymers under connement: single polymers, how they interact, and as model chromosomes

    How chromosomes are spatially organized in cells is not only important on its own merits but also benets other biological processes (e.g., accessibility of genes to proteins as for transcription). Accordingly, signicant eort has been made to understand the mechanism of chromosome organization in cells. The bacterial chromosome, occupying a sub-cellular space known as the nucleoid, is of particular interest, because of the intriguing roles of cylindrical connement in shaping chain molecules, .e., both single chains and the way they interact. For instance, the Escherichia coli (E. coli ) chromosome is often cartooned as a `sausage' (with a stretch connecting its ends, as shown in Fig. 1.1) or a `donut', under slow-growth or fast-growth conditions, respectively. A recent experimental study has shown that the nucleoid body (the sausage part) is overall linearly organized with loci precisely positioned in the cell. In particular, the width of both single-locus and interlocus-locus distributions is estimated to be within a few or 10% of the cell length. On the other hand, the spatial organization of the donut-shape chromosome is shown to be consistent with what we would expect from a symmetric ring polymer under cylindrical connement. What physical eects are responsible for the proper organization of chromosomes in a highly-conned intracellular space, the nucleoid?


    ...


  • 목차(Contents) 

    1. 표지 ... 1
    2. Preface ... 2
    3. Table of Contents ... 4
    4. 그림목차 ... 6
    5. 표목차 ... 14
    6. Chapter 1 Polymers under confinement: singlepolymers, how they interact, and asmodel c...
    1. 표지 ... 1
    2. Preface ... 2
    3. Table of Contents ... 4
    4. 그림목차 ... 6
    5. 표목차 ... 14
    6. Chapter 1 Polymers under confinement: singlepolymers, how they interact, and asmodel chromosomes ... 15
    7. 1.1 Simulation Methods ... 19
    8. 1.2 Modeling the nucleoid ... 21
    9. 1.3 Spatial organization of a model nucleoid ... 24
    10. 1.3.1 Spatial distributions of loci in the body ... 25
    11. 1.3.2 Partitioning of subchains ... 31
    12. 1.3.3 The parameter N1 - how to choose ... 32
    13. 1.3.4 Spatial Organization for the Crossing Region: uctuatingboundary model ... 33
    14. 1.3.5 Symmetrical vs. asymmetrical rings ... 37
    15. 1.4 Conclusions ... 40
    16. Acknowledgement ... 41
    17. Bibliography ... 42
    18. Appendix ... 45
    19. Chapter 2 Molecular crowding andchromosome-like organization of aring polymer in a cylindrical space ... 49
    20. 2.1 introduction ... 49
    21. 2.2 Simulation method ... 50
    22. 2.3 Results ... 51
    23. 2.4 Conclusions ... 57
    24. Bibliography ... 58
    25. Chapter 3 Future work ... 60
    26. References ... 61
    27. Chapter 4 Final statement of expenses ... 62
    28. Final statements of Expenses ... 63
    29. 끝페이지 ... 63
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